女童特发性中枢性性早熟中医证素特点研究

目的探讨女童特发性中枢性性早熟(ICPP)的中医证素特征。方法对确诊的61例女童特发性中枢性性早熟患儿,采用证素辨证和积分方法,提取病位、病性证素,对其进行统计分析。结果ICPP的病位证素为肾、肝,与脾、心、肺的差异有统计学意义(P<0.05)。病性证素为阴虚、热、湿、痰,阴虚、热积分高于湿、痰(P<0.05)。促性腺激素释放激素(GnRH)激发试验后LH峰值/FSH峰值与肾证素积分呈正相关(OR=7.922,P<0.05)。结论女童ICPP阴虚火旺最多见,可兼夹痰湿,病位主要在肝肾。

Study on TCM Syndrome Elements of Idiopathic Central Precocious Puberty in Girls

Objective To study the features of TCM syndrome elements of idiopathic central precocious puberty in girls.Methods Totally 61 patients with idiopathic central precocious puberty in girls were observed by syndrome elements differentiation and integral methods.The syndrome elements of the location and the nature of disease were extracted and analyzed to explore the TCM pathology characteristics of the disease.Results The statistical results of syndrome elements of the disease location showed the frequency of Shen and Gan was significantly higher than that of Pi,Xin and Fei respectively(P<0.05).The syndrome elements of the disease nature were yin deficiency,heat,dampness and phlegm.The results of syndrome elements of the disease nature showed the frequency of yin deficiency,heat was significantly higher than that of phlegm,dampness respectively(P<0.05).The LH/FSH ratio during the GnRH provocative test was postitively correlated with syndrome element of kidney(OR=7.922,P<0.05).Conclusion Yin deficiency and fire excess which might complicated with dampness and phlegm may be regarded as the essential pathogenesis of ICPP in girl,disease is positioned mainly on Shen and Gan.