冠状病毒感染的免疫应答及其致病机制研究进展

近年来冠状病毒感染在全球多次暴发流行，对全球公共卫生安全构成严重威胁。机体的免疫应答在病毒感染性疾病的发生、发展和转归中发挥重要作用，与病毒的致病性密切相关，对于控制和清除冠状病毒感染至关重要。本文在简述冠状病毒及其感染的相关疾病基础上，综述机体固有免疫应答和适应性免疫应答在冠状病毒发生、发展和致病中的作用和机制，为疾病的治疗和预防提供理论和实验依据。

Research progress of immune response and pathogenic mechanisms of coronavirus infection

In recent years, there have been many outbreaks of coronavirus infection around the world, posing a serious threat to global public health. The immune response of the body plays a critical role in the pathogenesis, development and outcome of viral infection disease, and it is closely related to the pathogenicity of the virus. It is very important for the control and elimination of coronavirus infection. In this paper, the coronavirus and related diseases are briefly introduced, and the role and mechanism of innate immune response and adaptive immune response in the occurrence, development and pathogenesis of coronavirus are reviewed to provide theoretical and experimental references for the treatment and prevention of diseases.