杏芎氯化钠注射液治疗急性缺血性脑卒中临床研究

目的:观察杏芎氯化钠注射液治疗急性缺血性脑卒中的疗效和安全性。方法:将急性缺血性脑卒中患者268例按照随机对照的原则分为对照组和观察组2组。2组均给予常规脑卒中治疗,对照组给予阿司匹林、氯吡格雷和依达拉奉治疗。观察组在对照组的基础上加用杏芎氯化钠注射液治疗。记录患者治疗前后神经功能缺损程度和日常生活能力、血清肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)和白细胞介素-6(IL-6)的含量,并比较疗效。结果:治疗后,2组神经学指标较前改善(P<0.05)。观察组美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,Barthel指数高于对照组,差异有统计学意义(P<0.05)。治疗后,2组血清相关指标较前改善(P<0.05)。观察组血清TNF-α、hs-CRP、IL-6水平低于对照组,差异有统计学意义(P<0.05)。观察组总有效率为90.30%,对照组总有效率为80.60%,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论:采用杏芎氯化钠注射液治疗急性缺血性脑卒中,能够有效降低炎症因子水平,促进患者神经功能恢复,提高患者生活质量。

Clinical Study on Floium Ginkgo Extract and Tertram Ethypyrazine Sodium Chloride Injection for Acute Ischemic Stroke

Objective:To observe the curative effect and safety of Floium Ginkgo extract and Tertram Ethypyrazine sodium chloride injection for acute ischemic stroke.Methods:A total of 268 cases of patients with acute ischemic stroke were randomly divided into the control group and the observation group.Both groups were given routine treatment for stroke;the control group was additionally treated with aspirin,clopidogrel and edaravone,and the observation group was additionally treated with Floium Ginkgo extract and Tertram Ethypyrazine sodium chloride injection based on the treatment of the control group.Before and after treatment,the degree of neurologic impairment,the activity of daily living and the content of tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)were recorded.The curative effect was compared.Results:After treatment,the neurological indexes in the two groups were improved when compared with those before treatment(P<0.05).The National Institute of Health Stroke Scale(NIHSS)score in the observation group was lower than that in the control group,and the Barthel index was higher than that in the control group,the difference being significant(P<0.05).After treatment,the related indexes in serum in the two groups were improved when compared with those before treatment(P<0.05).The levels of TNF-α,hs-CRP and IL-6 in serum in the observation group were lower than those in the control group,the difference being significant(P<0.05).The total effective rate was 90.30%in the observation group,higher than that of 80.60%in the control group,the difference being significant(P<0.05).Conclusion:The application of Floium Ginkgo extract and Tertram Ethypyrazine sodium chloride injection in treating acute ischemic stroke can effectively reduce the levels of inflammatory factors,promote the recovery of neurological function and improve the quality of life.