冠状病毒疫苗研究进展

进入21世纪以来，严重急性呼吸综合征冠状病毒（severe acute respiratory syndrome coronavirus, SARS-CoV）、中东呼吸综合征冠状病毒（Middle East respiratory syndromecoronavirus, MERS-CoV）及最新出现的严重急性呼吸综合征冠状病毒-2（severe acute respiratory syndrome coronavirus-2, SARS-CoV-2）等高致病性冠状病毒先后在人群中暴发流行，成为影响地区、国家乃至全球的重大公共卫生事件，研发特异性疫苗成为防控病毒流行的当务之急。本文综述了SARS-CoV和MERS-CoV疫苗的研究进展，望对SARS-CoV-2疫苗研制提供参考。

Research progress of coronavirus vaccine

Since the 21st century, several highly pathogenic coronaviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and the emerging severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have successively outbroken in the population, and become major public health events affecting regions, countries and even the whole world. Research and development of specific vaccines have become an urgent matter for the prevention and control of virus epidemics. This paper reviews the research progress of SARS-CoV and MERS-CoV vaccines, with the expectations to provide a reference for the development of SARS-CoV-2 vaccine.