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Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
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| Authors: | Campa Daniele Martino Alessandro Sainz Juan Buda Gabriele Jamroziak Krzysztof Weinhold Niels Vieira Reis Rui Manuel García-Sanz Ramón Jurado Manuel Ríos Rafael Szemraj-Rogucka Zofia Marques Herlander Lesueur Fabienne Bugert Peter Moreno Victor Szemraj Janusz Orciuolo Enrico Gemignani Federica Rossi Anna Maria Dumontet Charles Petrini Mario Goldschmidt Hartmut Landi Stefano Canzian Federico |
| Institution: | Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany. |
| Abstract: | Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies. |
| Keywords: | genetics cancer genetics cancer epidemiology haematological malignancies myeloma |
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