| 白细胞介素11基因治疗促进造血的实验研究 |
| |
| 引用本文： | 孙凯,金伯泉.白细胞介素11基因治疗促进造血的实验研究[J].中国免疫学杂志,1997,13(2):71-75. |
| |
| 作者姓名： | 孙凯 金伯泉 |
| |
| 作者单位： | 第四军医大学免疫学教研室，第三军医大学分子生物学教研室 |
| |
| 摘 要： | 白细胞介素１１是一种具有广泛生物学功能的造血生长因子，体内体外实验均显示ＩＬ－１１具有显著的造血促进作用。为了探讨ＩＬ－１１基因治疗应用于造血功能低下疾病的可能性，构建了含人ＩＬ－１１ｃＤＮＡ的逆转录病毒载体，并转染小鼠成纤维系ＮＩＨ－３Ｔ３，经是筛选获得３株表达ＩＬ－１１ 转染细胞亚克隆。
|
| 关 键 词： | 基因治疗 白细胞介素11 造血 |
EXPERIMENTAL STUDY OF THE EFFECTS OF INTERLEUKIN 11 GENETHERAPY ON MOUSE HEMATOPOIESIS |
| |
| Sun Kai,Jin Boquan,Zhu Yong et al.EXPERIMENTAL STUDY OF THE EFFECTS OF INTERLEUKIN 11 GENETHERAPY ON MOUSE HEMATOPOIESIS[J].Chinese Journal of Immunology,1997,13(2):71-75. |
| |
| Authors: | Sun Kai Jin Boquan Zhu Yong |
| |
| Institution: | Sun Kai,Jin Boquan,Zhu Yong et al.Department of Immunology,The Fourth Military Medical University,Xi'an 710032 |
| |
| Abstract: | Interleukin 11 is a multifunctional cytokine,especially in hematopoiesis.Successfully transfected the hIL 11 cDNA into murine fibroblast cell line NIH 3T3 cells and obtained the high secreting subclone 1E7 for further genetherapy experiment.Results showed that IL 11 genetherapy had significant effects on both normal and sublethally irradiated mice including an increase in the peripheral platelets of normal mice and marked acceleration of the recovery of peripheral WBC and platelets in sublethally irradiated mice.The results suggested that IL 11 could play an important role in the regulation of hematopoiesis under physical condition and IL 11 genetherapy had a potential value in hematopoiesis recovery. |
| |
| Keywords: | Genetherapy Interleukin 11 Hematopoiesis |
| 本文献已被 CNKI 维普 等数据库收录！ |
