| 恩替卡韦联合苦参素治疗HBeAg阳性慢性乙型肝炎的疗效观察 |
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| 引用本文： | 邵志林,张炳煌.恩替卡韦联合苦参素治疗HBeAg阳性慢性乙型肝炎的疗效观察[J].中国中西医结合消化杂志,2010,18(2). |
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| 作者姓名： | 邵志林 张炳煌 |
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| 作者单位： | 1. 黄石市中医院,肝病科,湖北,黄石,435000
2. 黄石市中医院,肝病科,湖北,黄石,435000;湖北中医学院,湖北,武汉,430065 |
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| 摘 要： | 目的]观察恩替卡韦(ETV)联合苦参素治疗HBeAg阳性慢性乙型肝炎(CHB)的疗效。方法]92例HBeAg阳性CHB患者随机分为2组,治疗组48例,每天服用ETV 0.5 mg,苦参素片0.6 g;对照组44例,每天服用ETV 0.5 mg。分别观察服药12、24、48周时的治疗效果。结果]对照组和治疗组在12、24、48周的HBV DNA阴转率分别为29.55%、40.91%、63.64%和43.75%、58.33%、83.33%,2组比较在12、24周时差异无统计学意义(P0.05),而在48周时差异有统计学意义(P0.05)。对照组和治疗组的HBeAg转阴率,在12、24周时分别为36.37%、43.75%和50.00%、64.59%,2组比较P0.05,而在48周时分别为59.09%和81.25%(P0.05)。对照组和治疗组的HBeAg/HBeAb血清转换率,12、24周时分别为29.55%、37.50%和40.91%、52.09%,2组比较P0.05,而在48周时分别为47.73%和68.75%,差异有统计学意义(P0.05)。结论]ETV联合苦参素治疗CHB可明显提高抗病毒治疗效果。
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| 关 键 词： | 乙型肝炎 慢性 乙型肝炎核心抗原 恩替卡韦 苦参素 |
Clinical effect of Entecavir combined with Oxymatrine on patients with HBeAg positive chronic hepatitis B |
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| SHAO Zhi-lin,ZHANG Bing-huang.Clinical effect of Entecavir combined with Oxymatrine on patients with HBeAg positive chronic hepatitis B[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2010,18(2). |
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| Authors: | SHAO Zhi-lin ZHANG Bing-huang |
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| Institution: | SHAO Zhi-lin1,ZHANG Bing-huang1,2(1Huangshi City Hospital of TCM,Huangshi 435000,China,2Hubei University of Traditional Chinese Medicine,Wuhan 430061,China) |
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| Abstract: | Objective]To observe the effects of Entecavir combined with oxymatrine on patients with HBeAg-positive chronic hepatitis B(CHB).Methods]Ninety-two cases were enrolled with HBeAg-positive CHB.They were randomly divided into treatment group(48 cases)and control group(44 cases),patents in treatment group daily received Entecavir 0.5 mg,Oxymatrine tablets 0.6 g and those in control group daily doses Entecavir 0.5 mg.Therapeutic effect was observed in 12,24,48 weeks after medication.Results]The HBV-DNA negati... |
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| Keywords: | chronic hepatitis B HBeAg positive Entecavir Oxymatrine |
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