Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy |
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Authors: | Yun-Jin Lee Joon Soo Lee Hoon-Chul Kang Dong-Seok Kim Kyu-Won Shim Soyong Eom Heung Dong Kim |
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Affiliation: | 1. Department of Pediatrics, Pusan National University Children’s Hospital, Pusan National University School of Medicine, Republic of Korea;2. Department of Pediatrics, Pediatric Epilepsy Clinics, Severance Children’s Hospital, Brain Research Institute, Yonsei University College of Medicine, Republic of Korea;3. Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, Republic of Korea;4. Department of Psychiatrics, Severance Hospital, Yonsei University College of Medicine, Republic of Korea |
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Abstract: | Purpose: to evaluate the outcomes and role of epilepsy surgery in children with intractable epileptic encephalopathy (EE). Methods: ninety-five children (64 boys, 31 girls) with intractable EE were treated by epilepsy surgery at Severance Children’s Hospital from 2003 to 2008. Surgical treatments included lobar resection, hemispherotomy and corpus callosotomy (CC). Seventy-six children were Lennox–Gastaut syndrome (LGS), and 19 had West syndrome. Results: of the 76 patients with LGS, CC was performed in 37 patients (48.7%), lobar resection in 29 (38.2%) and hemispherotomy in 10 (13.2%). Of the 19 patients with West syndrome, respective surgery was performed in 15 patients (78.9%) and CC in 4 (21.1%). Of the patients receiving respective surgery, Engel’s class I outcomes were achieved for 24 of 39 (61.5%) of LGS patients, and for 9 of 15 (60.0%) of West syndrome. Malformations of cortical development were commonly observed, appearing in 73.5% (36/49). In neuropsychiatric tests, 19 of 27 with LGS demonstrated improvement in postoperative cognitive function. More significant intellectual improvement correlated well with shorter epilepsy duration, good seizure outcomes, and decreased number of antiepileptic drugs. Conclusions: epilepsy surgery should be considered in treating childhood intractable EE with expectation of improvement of both seizure and cognitive outcomes, even in cases of LGS. |
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Keywords: | WS, West syndrome LGS, Lennox&ndash Gastaut syndrome AEDs, antiepileptic drugs EE, epileptic encephalopathy PET, positron emission tomography FDG, F18-labeled fluorodeoxyglucose SPECT, single photon emission computed tomography DTI-FT, diffusion tensor imaging-fiber tractography CC, corpus callosotomy ECoG, electrocorticography K-WISC, Korean-Wechsler intelligence scale for children K-WAIS, Korean-Wechsler adults intelligence scale FSIQ, full-scale IQ VIQ, verbal IQ PIQ, performance IQ DQ, developmental quotient MDI, mental developmental index PDI, performance developmental index SQ, social quotient Diff-IQ, difference between post- and preoperative IQ Diff-DQ, difference between post- and preoperative DQ ED, epileptic discharges MCDs, malformations of cortical development |
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