Expression of claudin-3 in the esophagus and larynx of rat reflux model |
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Authors: | Xiao Bing Xu Ying Hu Yang Wang Chui Jin Lai Tian Yu Zhang |
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Institution: | 1. Department of Otorhinolaryngology, EYE and ENT Hospital of Fudan University, China;2. Research Center, EYE and ENT Hospital of Fudan University, China |
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Abstract: | ObjectiveThe aim of this study was to investigate the association between laryngeal expression of claudin-3 and laryngopharyngeal reflux (LPR) in a rat reflux model.MethodsEight Wistar rats were divided into two groups. Four rats underwent total esophageal myectomy to induce reflux, and the remainder underwent a sham operation as a control. All animals were sacrificed 12 weeks after surgery to perform tissue histology and Western blot analysis.ResultsLymphocyte infiltration increased significantly in the study group in both esophageal and laryngeal samples (P = 0.001, 0.002, respectively). Both esophageal and laryngeal expressions of claudin-3 were significantly lower in the study group when compared with that in the control group (P = 0.045, 0.037, respectively).ConclusionThe results of this study suggest that a decrease in claudin-3 could be a sensitive indicator of reflux laryngitis in rats. |
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Keywords: | Laryngopharyngeal reflux Claudin-3 Gastroesophageal reflux disease |
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