Early onset and focal spike discharges as indicators of poor prognosis for myoclonic-astatic epilepsy |
| |
Authors: | Takahito Inoue Yukiko Ihara Yuko Tomonoh Noriko Nakamura Shinya Ninomiya Takako Fujita Hiroshi Ideguchi Sawa Yasumoto Bo Zhang Shinichi Hirose |
| |
Institution: | 1. Department of Pediatrics, School of Medicine, Fukuoka University, Fukuoka, Japan;2. Department of Biochemistry, School of Medicine, Fukuoka University, Fukuoka, Japan |
| |
Abstract: | Background: Myoclonic-astatic epilepsy (MAE) is an epileptic syndrome characterized by unique myoclonus, myoclonic-astatic, or astatic seizures in childhood. MAE prognosis vary from spontaneous remission to intractable seizures with profound mental retardation. Aim: Identifying early risk factors may optimize the treatment of children with MAE. Our hypothesis is early onset age and focal spike discharges on EEG indicate a poor MAE prognosis. Methods: Using the medical records of 9 children with MAE, we analyzed their clinical histories, EEG findings, and seizure symptoms. All patients were given follow-up observations/treatments by our department for at least 2 years after MAE onset. Results: Five of the patients were given favorable prognoses because their seizures disappeared within 2 years of onset; the other 4 received poor prognoses because their seizures continued more than 2 years. MAE onset in patient with refractory seizures was earlier than that in those with a favorable prognosis (7–24 months vs. 23–38 months). All the patients with refractory seizures showed moderate or severe mental retardation. Among the 5 patients with good prognosis, EEGs showed two with focal spike discharges and three with only generalized spike discharges. In contrast, all cases with a poor prognosis had focal spike discharges. Conclusions: MAE onset in patients with refractory seizures occurs earlier than in those with favorable prognosis. Prognosis was excellent when EEG findings show no focal spike discharges. Both early seizure onset and the focal spike discharges associated with MAE are indicators of poor prognosis. |
| |
Keywords: | Myoclonic-astatic epilepsy Doose syndrome Prognosis Early onset Focal spike discharges |
本文献已被 ScienceDirect 等数据库收录! |
|