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Quetiapine responsive catatonia in an autistic patient with comorbid bipolar disorder and idiopathic basal ganglia calcification
Authors:Makoto Ishitobi  Masao Kawatani  Mizuki Asano  Hirotaka Kosaka  Takashi Goto  Michio Hiratani  Yuji Wada
Affiliation:1. Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan;2. Department of Neuropsychiatry, University of Fukui, Japan;3. Research Center for Child Mental Development, University of Fukui, Japan;4. Hiratani Child Development Clinic, Fukui, Japan;5. Department of Pediatrics, University of Fukui, Japan
Abstract:Background: Bipolar disorder (BD) has been linked with the manifestation of catatonia in subjects with autism spectrum disorders (ASD). Idiopathic basal ganglia calcification (IBGC) is characterized by movement disorders and various neuropsychiatric disturbances including mood disorder. Case: We present a patient with ASD and IBGC who developed catatonia presenting with prominent dystonic feature caused by comorbid BD, which was treated effectively with quetiapine. Conclusion: In addition to considering the possibility of neurodegenerative disease, careful psychiatric interventions are important to avoid overlooking treatable catatonia associated with BD in cases of ASD presenting with both prominent dystonic features and apparent fluctuation of the mood state.
Keywords:Bipolar disorder   Quetiapine   Autism   Catatonia   Dystonia   Basal ganglia calcification
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