| 氨基酸分析仪法(过甲酸氧化)测定复方氨基酸注射液(18AA)中胱氨酸的含量 |
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| 引用本文： | 李煜,金瓯,郑国钢,洪利娅. 氨基酸分析仪法(过甲酸氧化)测定复方氨基酸注射液(18AA)中胱氨酸的含量[J]. 中国现代应用药学, 2014, 31(7): 871-874 |
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| 作者姓名： | 李煜 金瓯 郑国钢 洪利娅 |
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| 作者单位： | 浙江省食品药品检验研究院,浙江省食品药品检验研究院,浙江省食品药品检验研究院,浙江省食品药品检验研究院 |
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| 摘 要： | 目的 建立测定复方氨基酸注射液（18AA）中胱氨酸的含量方法。方法 采用柱前衍生-氨基酸分析仪测定。结果 胱氨酸在20.46∽184.10 g.mL 1内呈良好的线性关系（r=0.999 8）,平均回收率为100.8%,RSD（n=9）为0.91%。结论 本法专属性强、准确、快速、灵敏,可用于测定复方氨基酸注射液中胱氨酸的含量。
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| 关 键 词： | 复方氨基酸注射液 胱氨酸 含量测定 氨基酸分析仪 |
| 收稿时间： | 2013-09-25 |
| 修稿时间： | 2014-02-24 |
Determination of the Content of Cystine in Compound Amino Acids Injection (18AA) with Performic Acid Oxidation by Amino Acid Analyzer |
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| LI Yu,JIN Ou,ZHENG Guogang and HONG Liya. Determination of the Content of Cystine in Compound Amino Acids Injection (18AA) with Performic Acid Oxidation by Amino Acid Analyzer[J]. The Chinese Journal of Modern Applied Pharmacy, 2014, 31(7): 871-874 |
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| Authors: | LI Yu JIN Ou ZHENG Guogang HONG Liya |
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| Affiliation: | Zhejiang Institute for Food and Drug Control,Zhejiang Institute for Food and Drug Control,Zhejiang Institute for Food and Drug Control,Zhejiang Institute for Food and Drug Control |
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| Abstract: | OBJECTIVE To establish a method to determine the content of cystine in Compound Amino Acids injection （18AA）. METHODS The pre-column derivation and amino acid analyzer were adopted. RESULTS This method showed that the concentration-response relationship was linear over the range of 20.46-184.10 μg·mL-1（r=0.999 8）. The average recovery was 100.8% （RSD=0.91%, n=9）. CONCLUSION The method is specific, accurate, rapid, sensitive and suitable for the determination of content of cystine in Compound Amino Acids injection （18AA）. |
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| Keywords: | cystine content determination amino acid analyzer |
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