| 双丹胶囊质量标准的建立 |
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| 引用本文： | 毕琳琳,缪珊,李穆琼,杨倩,李骅,党碧艳,王四旺.双丹胶囊质量标准的建立[J].中国药师,2014(7):1237-1239. |
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| 作者姓名： | 毕琳琳 缪珊 李穆琼 杨倩 李骅 党碧艳 王四旺 |
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| 作者单位： | 第四军医大学药学系天然药物学教研室；西安 710032;第四军医大学药学系天然药物学教研室；西安 710032;第四军医大学药学系药物化学教研室;第四军医大学药学系天然药物学教研室；;第四军医大学药学系天然药物学教研室；;第四军医大学药学系天然药物学教研室；;第四军医大学药学系天然药物学教研室； |
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| 基金项目： | 陕西省科技专项项目（编号：2012K19-03-02 ） |
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| 摘 要： | 目的：建立双丹胶囊的质量标准.方法：采用TLC法对双丹胶囊中丹酚酸B成分进行鉴别,采用HPLC法测定胶囊中丹皮酚的含量.色谱条件为.Kromasil-C18柱;流动相：甲醇-0.1％磷酸（64∶36）;检测波长274 nm.结果：TLC分离度好,阴性对照无干扰;丹皮酚在26.2～131.0μg· ml-1范围内线性良好（r=0.999 8）,平均回收率为99.59％,RSD为0.85％（n＝6）.结论：该方法简便、准确,可以控制该制剂的质量.
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| 关 键 词： | 双丹胶囊 质量标准 丹皮酚 丹酚酸B |
| 收稿时间： | 2014/1/21 0:00:00 |
| 修稿时间： | 2014/3/19 0:00:00 |
Study on Quality Standard for Shuangdan Capsules |
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| Bi Linlin,Miao Shan,Li Muqiong,Yang Qian,Li Hu,Dang Biyan and Wang Siwang.Study on Quality Standard for Shuangdan Capsules[J].China Pharmacist,2014(7):1237-1239. |
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| Authors: | Bi Linlin Miao Shan Li Muqiong Yang Qian Li Hu Dang Biyan and Wang Siwang |
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| Institution: | Bi Linlin,Miao Shan,Li Muqiong,Yang Qian,Li Hua,Dang Biyan,Wang Siwang(Institute of Materia Medica,School of Pharmacy, the Fourth Military Medical University, Xi＇an 710032, China;Department of Medicinal Chemistry,School of Pharmacy, the Fourth Military Medical University, Xi＇an 710032, China) |
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| Abstract: | Objective：To establish a method for the quality control of Shuangdan capsules.Methods：A TLC method was used in the qualitative identification of salvianolic acid B,and an HPLC method was used to determine the content of paeonol in Shuangdan capsules.A Kromasil-C18 column（250 mm ×4.6 mm,5 μm） was used,the mobile phase was methanol-0.1％ phosphoric acid（64∶ 36）,and the detection wavelength was 274 nm.Results：The linear range of paeonol was 26.2-131.0 μg · ml-1 （r =0.999 8）.The average recovery for paeonol was 99.59％ （RSD =0.85 ％,n =6）.Conclusion：The method is simple and accurate,and suitable for the quality control of Shuangdan capsules. |
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| Keywords: | Shuangdan capsules Quality standard Paeonol Salvianolic acid B |
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