| FOLFOX方案治疗晚期复治的结直肠癌的临床观察 |
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| 引用本文： | 张宝南,金永胜,范志伟,高浩荣. FOLFOX方案治疗晚期复治的结直肠癌的临床观察[J]. 临床肿瘤学杂志, 2002, 7(6): 439-441 |
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| 作者姓名： | 张宝南 金永胜 范志伟 高浩荣 |
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| 作者单位： | 1. 214045,江苏,无锡市太湖肿瘤医院化疗科
2. 200032,上海,复旦大学附属肿瘤医院化疗科 |
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| 摘 要： | 目的 :观察FOLFOX(奥沙利铂、氟尿嘧啶和甲酰四氢叶酸钙 )方案在晚期复治的结直肠癌应用中的主要毒副反应和初步疗效。方法 :回顾性分析本院在 1999年 8月至 2 0 0 1年 10月收治的应用FOLFOX方案治疗的 34例晚期复治的结直肠癌患者的临床资料。结果 :本组患者主要毒副反应表现为 :外周感觉神经毒性 76 5 % ,均为Ⅰ～Ⅱ度 ;其次是骨髓抑制、恶心、呕吐、腹泻等。总有效率 2 6 5 % (9/ 34) ,其中完全缓解和部分缓解分别为 1例 (2 9% )和 8例 (2 3 5 % )。中位生存期 10个月 ,1年生存率 36 2 %。结论 :FOLFOX方案治疗晚期复治的结直肠癌的耐受性较好 ,疗效较满意 ,有临床应用价值
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| 关 键 词： | 结直肠癌 奥沙利铂 神经毒性 化疗 |
| 文章编号： | 1009-0460(2002)06-0439-03 |
| 修稿时间： | 2002-04-04 |
Administration of Oxaliplation and Leucovorin /5-Fluorouracil as Salvage Therapy in Advanced Colorectal Cancer |
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| Zhang Baonan,Gao Haorong,Jin Yongsheng,et al.. Administration of Oxaliplation and Leucovorin /5-Fluorouracil as Salvage Therapy in Advanced Colorectal Cancer[J]. Chinese Clinical Oncology, 2002, 7(6): 439-441 |
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| Authors: | Zhang Baonan Gao Haorong Jin Yongsheng et al. |
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| Affiliation: | Zhang Baonan,Gao Haorong,Jin Yongsheng,et al. Department of Chemotherapy,Wuxi Taihu Cancer Hospital,Jiangsu 214045 |
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| Abstract: | Objective:To observe main toxicity and efficacy of the regimen of oxalipiatin plus Leucovorin /5 Fluorouracil in advanced colorectal cancer.Methods:The clinical date of 34 patients with advanced colorectal cancer treated by FOLFOX regimen were retrospectively analyzed.Results:In all patients, the main toxicity was neuropenia, vomiting, diarrhea, leukopenia and throbopenia. The overall response rates was 26.5%. One was complete response and 8 were partial response respectively. Median survival time was 10 months. The 1 year survival rate was 36.2%.Conclusion:The results shows that regimen of FOLFOX as the salvage treatment for advanced colorectal cancer is receivable and preliminary efficacy is satisfied. |
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| Keywords: | Colorectal cancer Oxaliplation Neuropenia Chemotherapy |
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