2011年度本院临床SA感染分布及耐药性分析

目的调查2011年度该院临床金黄色葡萄球菌(SA)和耐甲氧西林金黄色葡萄球菌(MRSA)感染分布情况及其对常用抗菌药物的耐药率,为控制院内感染和临床合理使用抗菌药物提供依据。方法对该院2011年度检出的SA和MRSA药敏结果回顾性分析。结果 2011年度共检出SA146株(其中MRSA29株),菌株主要来源样本为痰液49株(33.56%),脓液37株(25.34%),泌尿生殖道分泌物11株(7.53%),其他样本49株(33.56%)。菌株分布前三位的科室是神经外科36株(24.66%)、创伤外科24株(16.44%)、呼吸消化科17株(11.64%)。分离出的146株SA对万古霉素、利奈唑胺全部敏感,其中MRSA对红霉素、克林霉素、四环素和环丙沙星呈现较高的耐药率,达70%以上;MRSA对各种抗菌药物的耐药率均明显高于甲氧西敏感金黄色葡萄球菌(MSSA)并呈现多重耐药。结论 SA临床感染分布和耐药率的分析能够为控制医院内MRSA的感染与流行及指导临床合理用药提供科学的理论依据。

Study on the hospital staphylococcus aureus clinical distribution and drug rsistance in 2011

Objective To investigate the 2011 hospital Staphylococcus aureus(SA) and methicillin-resistant Staphylococcus aureus(MRSA) clinical distribution and the resistance to commonly used antimicrobial rate for the control of nosocomial infection and clinical rational use of antimicrobial agents provide a basis.Methods SA and MRSA drug sensitivity results of 2011 in this hospital were retrospectively analyzed.Results One year have been isolated SA 146 strain,mainly from sputum of 49 strains(33.56%),pus 37 strains(25.34%),urinary and genital tract secretions of 11 strains(7.53%).Strain distribution three department is the Department of Neurosurgery 36 strains(24.66%),24 strains(16.44%) trauma surgery,respiratory digestive department 17 strains(11.64%).Among 29 strains of MRSA(19.8%).Isolation of 146 strains of SA to vancomycin,linezolid all sensitive to erythromycin,clindamycin,which MRSA,tetracycline and ciprofloxacin showed higher resistance rates,more than 70%.MRSA on a variety of antibiotic resistance rates were significantly higher than that in MSSA and multiple resistance.Conclusion Based on the SA clinical distribution and drug resistance rate of analysis,to take measures to control nosocomial infection and prevalence of MRSA and to guide clinical rational drug use.