| 结核病患者T细胞亚群检测临床意义分析 |
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| 引用本文： | 栗群英,吴丽娟,陈莉,杨利. 结核病患者T细胞亚群检测临床意义分析[J]. 国际检验医学杂志, 2012, 33(19): 2346-2347 |
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| 作者姓名： | 栗群英 吴丽娟 陈莉 杨利 |
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| 作者单位： | 1. 成都军区总医院检验科,四川成都,610083
2. 成都军区总医院检验科,四川成都,610083;成都医学院检验系2007级,四川成都,610083 |
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| 摘 要： | 目的 探讨结核病患者外周血T细胞亚群检测的临床意义.方法 采用流式细胞术检测196例健康者、84例结核病患者及100例呼吸系统非结核杆菌感染患者外周血T细胞亚群、CD3+CD4-CD8-双阴性细胞(DNT)和CD3+CD4+CD8+双阳性细胞(DPT)百分含量和绝对含量,并进行比较分析.结果 与健康者相比,结核病患者DNT、DPT百分含量减少(P＜0.05),总T细胞、T4细胞、T8细胞、DNT、DPT绝对含量均减少(P＜0.05).结论 T细胞亚群,尤其是DNT和DPT可作为判断结核患者免疫状态、指导用药和疗效观察的指标.
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| 关 键 词： | 结核 T细胞亚群 流式细胞术 |
Clinical significance of T-cell subsets in peripheral blood of patients with tuberculosis |
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| Li Qunying , Wu Lijuan , Chen Li , Yang Li. Clinical significance of T-cell subsets in peripheral blood of patients with tuberculosis[J]. International Journal of Laboratory Medicine, 2012, 33(19): 2346-2347 |
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| Authors: | Li Qunying Wu Lijuan Chen Li Yang Li |
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| Affiliation: | 1,2(1.Department of Medical Laboratory,Chengdu Military General Hospital,Chengdu,Sichuan 610083,China;2.Grade 2007,Department of Medical Laboratory,Chengdu Medical College,Chengdu,Sichuan 610083) |
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| Abstract: | Objective To explore the clinical significance of T-cell subset in peripheral blood of patients with tuberculosis.Methods Three color flow cytometry was used to determine the peripheral blood T-cell subset,CD3+CD4-CD8-double-negative cell(DNT) and CD3+CD4+CD8+ double-positive cell(DPT) in 196 healthy subjects,84 patients with tuberculosis and 100 patients with respiratory apparatus non-tubercle bacillus infection.Results Compared with healthy subjects,the percentages of DNT and DPT in patients with tuberculosis decreased(P<0.05) and the absolute quantities of total T cell,T4 cell,T8 cell,DNT and DPT also reduce significantly(P<0.01).Conclusion T-cell subsets,especially DNT and DPT might be helpful indexes in immune state judgement,drug guidance and therapeutic effect observation for patients with tuberculosis. |
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| Keywords: | tuberculosis T-cell subset flow cytometry |
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