呼吸科抗菌药物的使用与铜绿假单胞菌耐药率的宏观量化关系研究

目的探讨某三甲医院呼吸科2005～2009年抗菌药物使用与铜绿假单胞菌耐药水平变化之间的关系。方法统计呼吸科2005～2009年每半年的药物"类"和药物"种"的消耗情况,并监测铜绿假单胞菌临床耐药率,然后对两者进行相关分析。结果头孢三代药物使用2005～2009年呈整体下降趋势,且和铜绿假单胞菌对主要抗菌药物的耐药率呈正相关;喹诺酮类药物的使用2005～2009年呈整体上升趋势,且和铜绿假单胞菌对主要抗菌药物的耐药率呈负相关;加酶抑制剂类(包括头孢三代加酶抑制剂类和青霉素加酶抑制剂类等)药物的使用,均与铜绿假单胞菌对抗菌药物的耐药率无正相关关系。结论在用药结构中,适当减少头孢三代抗菌药物的比例,适当增加喹诺酮类、加酶抑制剂类抗菌药物的比例,有利于减少铜绿假单胞菌耐药性产生。

Research on quantitive relationship between the consumption of antibacterial agents and resistance rates of Pseudomonas aeruginosa in respiratory unit

Objective To investigate the quantitive relationship between the usage of antibacterial agents and resistance rates of Pseudomonas aeruginosa(PAE) in respiratory unit.Methods The data of consumption of different kinds of antibacterial agents were collected from January 2005 to December 2009 semi-annually,at the same time,clinical resistance rates of pathogenic PAE were calculated.The correlation coefficient between the antibacterial agent usage and the resistance rate of PAE was calculated.Results The usage of the third generation Cephalosporin showed an trend of decline and there was a significant positive correlation between its consumption and the resistance rates of PAE of the antibacterial agent commonly used;and conversely the useage of the Quinolones showed an upward trend and there was a significant negative correlation between its consumption and the resistance rate of PAE.There was no positive correlation between the usage of the biotic with enzyme inhibitors and the resistance rates.Conclusion Giving a proper reduction in the use of the third generation Cephalosporin,a proper increase in the use of the Quinolone and the biotic with enzyme-inhibitor,the resistance rates of PAE could be reduced.