Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor |
| |
Authors: | Cario Gunnar Skokowa Julia Wang Zheng Bucan Vesna Zeidler Cornelia Stanulla Martin Schrappe Martin Welte Karl |
| |
Affiliation: | Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany. |
| |
Abstract: | Apoptosis is accelerated in the myeloid progenitor cells of patients with severe congenital neutropenia (CN). Granulocyte colony-stimulating factor (G-CSF) increases neutrophil numbers in most CN patients. The effect of G-CSF on apoptosis in CN was analysed by apoptosis rate and expression of anti- and pro-apoptotic factors. G-CSF-treated patients showed higher apoptosis frequency, lower expression of bcl-2 and bcl-xL, but higher expression of bfl-1/A1 and mcl-1. Caspase 9 was highly expressed in patients and controls after G-CSF administration. Thus, G-CSF acts on apoptosis regulation, but additional mechanisms leading to the increase of neutrophil numbers must be assumed. |
| |
Keywords: | severe congenital neutropenia myeloid progenitor cells granulocyte colony-stimulating factor apoptosis bcl-2 family members |
本文献已被 PubMed 等数据库收录! |