粒细胞集落刺激因子与异基因造血干细胞移植中移植物抗宿主病及移植物抗白血病的免疫调节效应

文章从细胞水平、动物模型、临床应用等方面对粒细胞集落刺激因子在移植物抗宿主病和移植物抗白血病中的免疫调节作用作进一步的研究。得出结论：粒细胞集落刺激因子可从T细胞、抗原递呈细胞、调节性T细胞、自然杀伤细胞等途径发挥其免疫调节作用，诱导移植物中的T细胞产生免疫耐受，使得移植物抗宿主病和移植物抗白血病效应产生分离，从而改善异基因造血干细胞移植患者的预后，因此，输注经粒细胞集落刺激因子动员的供者淋巴细胞是其中值得关注的、有前途的一种方法。但其作用的途径机制、输注的时机、输注的细胞数等仍有待进一步的实验室和临床研究。

Immunological regulation of granulocyte colony-stimulating factor and allo-hemopoietic stem cell transplantation in graft versus host disease and graft versus leukemia

Immunological regulation effects of granulocyte colony-stimulating factor (G-CSF) are studied from cell level, animal models and clinical application in graft versus host disease and graft versus leukemia. G-CSF can induce immunological regulation effect through T-cell, antigen presenting cell, regulatory T-cell, natural killer cell and so on. G-CSF can induce T-cell tolerance of transplantation and separate graft versus host disease and graft versus leukemia effect to improve prognosis of patients of allo-hemopoietic stem cell transplantation. G-CSF-mobilized donor lymphocyte infusion is a hopeful method which we should pay more attention to. But, effect mechanism of G-CSF-mobilized donor lymphocyte infusion, what is the appropriate time to infusion and how many cells to infuse are not so clear now. It needs us to make further experimental and clinical researches.