多层螺旋CT肺密度测定对结缔组织病肺问质病变的早期诊断

目的探讨多层螺旋CT(MSCT)肺密度测定对结缔组织病(CTD)肺间质病变(ILL)早期诊断的临床意义。方法对222例CTD患者及50名正常对照者，应用MSCT附带的Pulmo自动评估软件进行上、中、下肺区的密度测定，并同时进行肺高分辨扫描(}-IR(_1、)，分析二者的变化与CTD伴ILL的关系。结果222例cm患者中197例平均肺密度有不同程度的增高，25例平均肺密度正常。157例HRCT有不同程度的肺间质病变，65例HRCT正常。50名正常对照者HRCT均正常，8名平均肺密度有不同程度的增高，42名平均肺密度正常。结论采用MSCT与HRCT对CTD伴ILL的检测结果差异有统计学意义，P=0．000(双侧)，因此MSCT平均肺密度测定对早期诊断CTD伴ILL比HRCT更敏感，更有临床意义。

Multi-spiral computed tomography to measure lung-tissue density in early diagnosis of pulmonary interstitial lesions during connective tissue disease

Objective To investigate the early diagnosis of t he interstitial lung lesion (ILL) of connective tissue disease(CTD) by measu ring pulmonary density with multi-spiral CT(MSCT).Methods Meas uring pulmonary density with MSCT was performed in 222 patients with CTD and 50 normal individuals.The average attenuation values and their frequency distributi on and inferior lung regions were measured with Pulmo semiautomatic evaluation s oftware.All patients also had their lungs receive high-resolution computed tomo graphy (HRCT).The changes of pulmonary densities measured by MSCT and HRCT were analyzed statistically.Results One hundred and ninety-seven of 2 22 cases with CTD showed their average pulmonary density was higher,and 25 was normal.One hundred and fifty-seven cases of 222 cases receiving HRCT showed abnormal density,but 65 cases showed normal;50 normal controls showed all norm al.Forty-two of 50 normal controls showed their average pulmonary density norma l,and 8 abnormal.Conclusion The data obtained showed a signifi cant difference between MSCT and HRCT (P=0.000,bilaterally),ave rage lung-tissue density determination by MSCT is more sensitive on early diagn osing pulmonary interstitial lesions during connective tissue disease than that by HRCT,with more clinical significance.