萆薢分清丸联合头孢唑肟钠治疗尿路感染的临床研究

目的探讨萆薢分清丸联合头孢唑肟钠治疗尿路感染的临床疗效。方法选取2015年11月—2017年1月在上海市宝山区中西医结合医院进行治疗的尿路感染患者200例,随机分为对照组(100例)和治疗组(100例)。对照组患者静脉滴注注射用头孢唑肟钠,2 g/次,2次/d。治疗组在对照组的基础上口服萆薢分清丸,6 g/次,2次/d。两组患者均连续治疗7 d。观察两组患者临床效果,比较两组患者治疗前后临床症状改善时间和血清细胞因子水平。结果治疗后,对照组和治疗组临床有效率分别为83.00%和97.00%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组患者尿频、尿急和尿痛改善时间比对照组显著缩短,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者血清降钙素原(PCT)、C反应蛋白(CRP)和白细胞介素-6(IL-6)水平均显著降低,同组比较差异具有统计学意义(P0.05);且治疗组患者的细胞因子水平明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论萆薢分清丸联合头孢唑肟钠可有效改善尿路感染患者临床症状,降低机体PCT水平,具有一定的临床推广应用价值。

Clinical study on Bixie Fenqing Pills combined with ceftizoxime sodium in treatment of urinary tract infection

Objective To evaluate the clinical efficacy of Bixie Fenqing Pills combined with ceftizoxime sodium in treatment of urinary tract infection. Methods Patients (200 cases) with urinary tract infection in Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine in Shanghai from November 2015 to January 2017 were randomly divided into control (100 cases) and treatment (100 cases) groups. Patients in the control group were iv administered with Ceftizoxime Sodium for injection, 2 g/time, twice daily. Patients in the treatment group were po administered with Bixie Fenqing Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and clinical symptom improvement time and serum cytokine levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.00% and 97.00%, respectively, and there were differences between two groups (P<0.05). After treatment, the improvement time of frequent micturition, urgency to urinate and odynuria in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the PCT, CRP and IL-6 levels in two groups were significantly decreased, and there were differences in the same group (P<0.05). And the serum cytokine levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Bixie Fenqing Pills combined with ceftizoxime sodium can effectively improve the clinical symptoms in treatment of urinary tract infection, and reduce the PCT, CRP and IL-6 levels, which has a certain clinical application value.