金天格胶囊联合美洛昔康治疗膝骨关节炎的疗效观察

目的探讨金天格胶囊联合美洛昔康治疗膝骨关节炎的临床疗效。方法选取2016年4月—2017年7月在内蒙古医科大学附属医院就诊的膝骨关节炎患者83例,随机分为对照组(42例)和治疗组(41例)。对照组口服美洛昔康片,2片/次,3次/d。治疗组在对照组治疗基础上口服金天格胶囊,3粒/次,3次/d。两组患者均连续治疗12周。观察两组的临床疗效,比较两组治疗前后Lysholm评分、膝关节屈曲度、VAS评分的变化情况。结果治疗后,对照组和治疗组的总有效率分别为73.81%、82.93%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者疼痛感评分、内外翻畸形评分、关节活动度评分、主动延伸受限评分、行走能力评分、日常活动评分、总分、膝关节屈曲度均明显增加,VAS评分显著降低,同组治疗前后差异有统计学意义(P0.05);治疗后,治疗组疼痛感评分、内外翻畸形评分、关节活动度评分、主动延伸受限评分、行走能力评分、日常活动评分、总分、膝关节屈曲度显著高于对照组,VAS评分低于对照组,两组比较差异有统计学意义(P0.05)。结论金天格胶囊联合美洛昔康治疗膝骨关节炎具有较好的临床疗效,可提高膝关节功能的康复效果,降低患者疼痛,具有一定的临床推广应用价值。

Clinical observation on Jintiange Capsules combined with meloxicam in treatment of knee osteoarthritis

Objective To investigate the clinical effect of Jintiange Capsules combined with meloxicam in treatment of knee osteoarthritis. Methods Patients (83 cases) with knee osteoarthritis in Affiliated Hospital of Inner Mongolia Medical University from April 2016 to July 2017 were randomly divided into control (42 cases) and treatment (41 cases) groups. Patients in the control group were po administered with Meloxicam Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Jintiange Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the changes of Lysholm scores, knee flexion degree and VAS scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 73.81% and 82.93%, respectively, and there were differences between two groups (P<0.05). After treatment, pain sensitivity score, internal and external deformity score, joint activity score, active extension restricted score, walking ability score, daily activity score, total score, and knee flexion degree in two groups were increased, but VAS score was decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, pain sensitivity score, internal and external deformity score, joint activity score, active extension restricted score, walking ability score, daily activity score, total score, and knee flexion degree in the treatment group were higher than those in the control group, but VAS score was lower than that in the control group, and there was difference between two groups (P<0.05). Conclusion Jintiange Capsules combined with meloxicam has clinical curative effect in treatment of knee osteoarthritis, and can improve the function of the knee, also can reduce the pain, which has a certain clinical application value.