Primary primitive neuroectodermal tumor of the kidney: A case report |
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Authors: | Suna Erk?l?ç Co?kun Özsaraç N Emrah Koçer Ahmet Erba?c? |
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Institution: | Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. serk52@yahoo.com |
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Abstract: | There are nearly 50 PNET cases in the literature with primary renal localization. The mean age for renal PNET is 28 but it
can be seen in a wide range between 4 and 69 years. In this atypical localization PNET may be mistaken with a variety of small
round cell tumors, particularly with blastema predominant Wilms’ tumor and due to its distinctive prognostic and therapeutic
features differential diagnosis is very important. Immunohistochemical studies are useful in discriminating PNET from other
renal small round cell tumors. Renal PNETs tend to metastasize at early stages and they have a high rate of recurrence. Our
case is a 45-year-old male presented with left flank pain and hematuria. In computerized tomography a mass in left kidney
was observed and nephrectomy was performed. Histopathologic examination revealed a small round cell tumor with rosettes and
pseudorosettes. Immunohistochemically the lesion was diffuse strong positive with CD99 and NSE, negative with LCA, pancytokeratin,
vimentin, desmin, smooth muscle actin, chromogranine A and S-100. At the time of diagnosis the pathologic stage of the tumor
was T1aN0Mx. The patient did not take any further therapy and in 1-year follow-up no local recurrence or distant metastasize
occurred. |
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Keywords: | Ewing sarcoma Kidney Primitive neuroectodermal tumor (PNET) Small round cell tumor |
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