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| 基因重组人骨形成蛋白-2对培养骨髓细胞的生物学效应 | |
| 引用本文： | 陈富林,任卫红,蒲勤,毛天球,杨连甲.基因重组人骨形成蛋白-2对培养骨髓细胞的生物学效应[J].第四军医大学学报,1999,20(2):143-145. |
| 作者姓名： | 陈富林 任卫红 蒲勤 毛天球 杨连甲 |
| 作者单位： | 1. 第四军医大学秦都口腔医学院颌面外科,陕西,西安,710033 2. 第四军医大学秦都口腔医学院病理科 3. 第四军医大学生物化学教研室 4. 第四军医大学秦都口腔医学院病理科,陕西,西安,710033 |
| 摘 要： | 目的 骨髓是机体重要的造血器官，其中的单个核细胞主要是单核细胞和巨噬细胞，骨髓组织在骨损伤修复过程中也发挥重要的作用，为提高骨形成蛋白（ＢＭＰ）修复骨缺损的能力。方法 本实验观察了基因重组人骨形成蛋白－２（ｒｅｃｏｍｂｉｎａｎｔｈｕｍａｎＢｏｎｅＭｏｒｐｈｏｇｅｎｅｔｉｃＰｒｏｔｅｉｎ－２，ｒｈＢＭＰ２）对培养骨髓细胞生物学活性的影响。结果 低浓度的ｒｈＭＢＰ２）对培养骨髓细胞生物学活性的影响。结 |
| 关 键 词： | 骨髓细胞 细胞分裂 细胞分化 |
| 修稿时间： | 1998-03-12 |
Biological effects of recombinant human bone morphogenetic protein-2 on cultured bone marrow cells |
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| CHEN Fu-Lin,REN Wei-Hong,PU Qing,MAO Tian-Qiu,YANG Lian-Jia.Biological effects of recombinant human bone morphogenetic protein-2 on cultured bone marrow cells[J].Journal of the Fourth Military Medical University,1999,20(2):143-145. | |
| Authors: | CHEN Fu-Lin REN Wei-Hong PU Qing MAO Tian-Qiu YANG Lian-Jia |
| Abstract: | AIM: Bone marrow cells play an important role inthe repair of bone injury and to improve the ability of bone defect repair of bone morphogenetic protein (BMP ). METHODS: To investigate the effects of recombinant human bonemorphogenon-2 (rhBMP2 ) on biological characters of culturedbone marrow cells in this experiment. RESULTS: The resultsclearly demonstrated that rhBMP2 could increase alkalinephosphate activity and total cel1ular protein of bone marrow cells significantly at low dose(<0. 16 mg/L), with a dose responsible manner, and could also increase cell proliferation athigh dose (>0. 16 mg/L). CONCLUSION: So bone marrowcells were also target cells of rhBMP2, rhBMP2 could inducebone marrow cel1s to differentiate into osteoblastic phenotypeand stimulate bone marrow cells to proliferate. This indicatedthat transplantation of bone marrow cells accompanied withBMP may be an applicable method for bone defect repair. |
| Keywords: | rhBMP2 |
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