A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure |
| |
| Authors: | Kai Li Yuting Zhu Qiang Zhang Xiaoli Shi Feng Liang Dong Han |
| |
| Institution: | 1.The State Key Laboratory for Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China;2.Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China; (Y.Z.); (Q.Z.); (D.H.);3.School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China |
| |
| Abstract: | Although there have been many studies on using hydrogels as substitutes for natural extracellular matrices (ECMs), hydrogels that mimic the structure and properties of ECM remain a contentious topic in current research. Herein, a hierarchical biomimetic fiber hydrogel was prepared using a simple strategy, with a structure highly similar to that of the ECM. Cell viability experiments showed that the hydrogel not only has good biocompatibility but also promotes cell proliferation and growth. It was also observed that cells adhere to the fibers in the hydrogel, mimicking the state of cells in the ECM. Lastly, through a rat skin wound repair experiment, we demonstrated that this hydrogel has a good effect on promoting rat skin healing. Its high structural similarity to the ECM and good biocompatibility make this hydrogel a good candidate for prospective applications in the field of tissue engineering. |
| |
| Keywords: | hydrogel hierarchy fiber self‑ healing wound dressing |
|
|
