In vivo protein markers of human peritoneal mesothelial cells: do they differ according to their anatomical sites? |
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| Authors: | Valérie Serre Sophie Tézenas du Montcel Linda Kontula Monique Simon Emmanuelle Perret Patrick Nédellec Patrick Vicart Jean-Jacques Duron |
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| Institution: | Laboratoire Cytosquelette et Développement, CNRS UMR 7000, Faculté de Médecine Pitié-Salpêtrière, Paris, France. |
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| Abstract: | OBJECTIVE: To highlight the in vivo protein markers in human peritoneal mesothelial cells according to their anatomical distribution and their interest in theories of peritoneal repair. DESIGN: Clinical laboratory study. SETTING: University Hospital, France. PATIENTS: Sampling of mesothelial cells during 8 laparotomies by impression smears. MAIN OUTCOME MEASURES: Immunochemical semiquantitative measures of proteins. RESULTS: There were uniform ratios of protein markers among the whole peritoneal mesothelial cell population, whatever their anatomical origin (liver, stomach, omentum, small bowel, and abdominal wall). CONCLUSION: This is consistent with the surrounding uninjured mesothelial cells or the exfoliated mesothelial cells, or both, having a role in postoperative peritoneal mesothelial repair. |
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