产超广谱β-内酰胺酶大肠埃希菌的临床调查

目的了解本院2008年住院患者产超广谱β-内酰胺酶大肠埃希菌的感染情况为临床防控及治疗产超广谱β-内酰胺酶大肠埃希菌引起的感染提供科学依据。方法对2008年1-12月间本院感染大肠埃希菌的住院患者进行调查,并进行药敏检测,结果依据2009年CLSI标准,采用WHONET 5.4软件进行统计分析。结果本院在2008年1-12月间的住院患者中,检出大肠埃希菌306例,ESBLs阳性率41.6%;产ESBLs大肠埃希菌检出较多的科室为泌尿外科（24例,占17.0%）,检出标本最多的为尿标本（63例,占44.7%）;药敏结果为ESBLs与不产ESBLs大肠埃希菌对多种抗菌药物均有不同程度的耐药性,而产ESBLs大肠埃希菌的耐药率要高于不产ESBLs大肠埃希菌。结论2008年间中国医大一院某些科室如泌尿外科,外科ICU等存在产ESBLs大肠埃希菌的短期暴发流行。

Clinical Surveys of E.coli.Producing Extended-Spectrum beta-lactamase

Objective To investigate the patients infected by extended-spectrum beta-lactamase（ESBLs） producing bacteria and their distribution,and make drug sensitivity testing for separated bacteria,to provide a reasonable proof for preventing and controlling nosocomial infection by ESBLs producing bacteria.Methods To study of the clinical data of cases with hospital aquired infection by Positive-ESBLs bacteria and those of negative-ESBLs baeteria and make drug sensitivity testing for separated bacteria of the first affiliated hospital of china medical university in 2008.Results The positive rate of ESBLs-producing Escherichia coli germs in 306 Escherichia coli germs is 46.1%.The highest number of cases is the urology department（24 cases,accounting for 17.0%）,the largest number of specimens detected is urine specimens（63 cases,accounting for 44.7%）.Conclusion There is short term outbreak of ESBLs-producing Escherichia coli in some departments such as urology and surgical ICU in the first affiliated hospital of china medical university in 2008.