Minute perivascular epithelioid cell (PEC) nests in the abdominal lymph nodes—a putative precursor of PEComa |
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Authors: | Toru Nagasaka Yoshiko Murakami Eiichi Sasaki Waki Hosoda Toru Nakanishi Yasushi Yatabe |
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Institution: | 1. Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan;2. Department of Gynecological Oncology, Aichi Cancer Center Hospital, Nagoya, Japan |
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Abstract: | A perivascular epithelioid cell tumor (PEComa) is a peculiar growth defined as a mesenchymal tumor composed of histologically and immunohistochemically distinct perivascular epithelioid cells (PECs). Because neither normal counterparts nor precursor lesions of PEComa have been identified, we examined minute PEC nests, ranged from 0.8 mm to 10 mm, to investigate the possible origin of the PEComa. We examined a total of 80 677 para‐aortic and pelvic lymph nodes that were systematically dissected from 1656 patients for gynecological malignancies. The identified lesions were confirmed immunohistochemically with multiple PEC markers, including smooth muscle actin, HMB45, melan‐A, MiTF, ER and PgR. A total of 66 minute PEC nests were found in 21 patients (1.3% of the total population) with an average frequency of 3.1 lesions per patient. In cases of multiple involvement, 11 of 13 nests were located at the same level of multiple lymph node or on continuous levels. The lesions were preferentially distributed at the level of para‐aortic and high pelvic lymph nodes. All nests were positive for actin and HMB45, whereas the other markers were positive with varying frequencies. The minute PEC nests may be associated with the possible normal counterpart of PEComas. |
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Keywords: | angiomyolipoma lymphangioleiomyomatosis PEComa perivascular epithelioid cell |
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