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| 胰岛素抵抗大鼠血糖正常阶段心肌内皮素1、内皮型一氧化氮合酶表达的改变 | |
| 引用本文： | 刘颖,何金,刘志民,赵瑛,刘会敏. 胰岛素抵抗大鼠血糖正常阶段心肌内皮素1、内皮型一氧化氮合酶表达的改变[J]. 中华内分泌代谢杂志, 2006, 22(1): 28-29 |
| 作者姓名： | 刘颖 何金 刘志民 赵瑛 刘会敏 |
| 作者单位： | 1. 200003,上海,第二军医大学附属长征医院内分泌科 2. 200003,上海,第二军医大学附属长征医院病理科 3. 200003,上海,第二军医大学附属长征医院神经内科 |
| 基金项目： | 上海市卫生局医学发展基金重点项目资助课题[2001ZD002（3）] |
| 摘 要： | 高糖饲料喂养SD大鼠建立胰岛素抵抗（In）模型。12周时IR大鼠心室肌内皮素（ET）-1蛋白及mRNA表达升高，内皮型一氧化氮合酶（eNOS）蛋白和mRNA表达降低。表明高糖膳食诱导的IR大鼠在IR早期已存在心肌ET-1与eNOS平衡的异常。 |
| 关 键 词： | 胰岛素抵抗 内皮素1 一氧化氮合酶 心肌 |
| 收稿时间： | 2004-08-10 |
| 修稿时间： | 2004-08-10 |
Alteration of myocardial ET-1 and eNOS gene expressions in insulin-resistant rats during normal glycemia stage |
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| LIU Ying,HE Jin,LIU Zhi-min,ZHAO Ying,LIU Hui-min. Alteration of myocardial ET-1 and eNOS gene expressions in insulin-resistant rats during normal glycemia stage[J]. Chinese Journal of Endocrinology and Metabolism, 2006, 22(1): 28-29 | |
| Authors: | LIU Ying HE Jin LIU Zhi-min ZHAO Ying LIU Hui-min |
| Affiliation: | Department of Endocrinology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003 |
| Abstract: | Insulin-resistant (IR) rat model (n=10) was established by feeding high-glucose diet. SD rats fed with normal diet (n=10) were used as control (CN) group. By the 12th week, the levels of endothelin-1 (ET-1) protein and mRNA of myocardium in IR group were higher than those in CN group while levels of eNOS protein and mRNA in IR group were lower than those in CN group, showing the imbalance between ET-1 and eNOS in myocardium of high-glucose diet induced IR rats during early IR stage. |
| Keywords: | Insulin resistance Endothelin-1 Nitric-oxide synthase Myocardium |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |