| 抑郁症的生化病理机制探讨 |
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| 引用本文： | 陈珏,肖泽萍,林治光,王克勋,蔡军.抑郁症的生化病理机制探讨[J].临床精神医学杂志,2002,12(4):193-195. |
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| 作者姓名： | 陈珏 肖泽萍 林治光 王克勋 蔡军 |
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| 作者单位： | 200030,上海市精神卫生中心 |
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| 基金项目： | 上海市卫生系统百人计划资助 (97BR0 3 0 ) |
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| 摘 要： | 目的：从神经递质与神经内分泌角度探讨抑郁症的生化病理机制。方法：采用高效液相色谱法及放射免疫测定法，分别测定15例抑郁症患者和27例正常对照者血小板5-羟色胺（5-HT）含量及血浆催乳素（PRL）含量，地塞米松抑制实验（DST）皮质醇含量。结果：抑郁症组血小板5-HT水平低于正常对照组，血浆基础皮质醇及服地塞米松后皮质醇均高于正常对照组，DST阳性率高于正常对照组。结论：抑郁症患者存在神经递质和神经内分泌功能的紊乱，抑制症的5-HT能假说能解释其某些内分泌功能紊乱。
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| 关 键 词： | 抑郁症 5－羟色胺 催乳素 地塞米松抑制实验 病理 |
| 文章编号： | 1005-3220(2002)04-0193-03 |
| 修稿时间： | 2001年12月24 |
Detection on pathophysiological mechanism of depression |
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| Chen Jue,Xiao Zeping,Lin Zhiguang,et al..Detection on pathophysiological mechanism of depression[J].Journal of Clinical Psychological Medicine,2002,12(4):193-195. |
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| Authors: | Chen Jue Xiao Zeping Lin Zhiguang |
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| Institution: | Chen Jue,Xiao Zeping,Lin Zhiguang,et al.Shanghai Mental Health Center,Shanghai 200030 |
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| Abstract: | Objective:To explore the pathophysiological mechanism of depression from the angles of neurotransmitter and neuroendocrine. Method:Platelet serotonin level was determined with high performance liquid chromatograhy (HPLC) while plasma prolactin and cortisol levels were determined with radioimmunoassay. Results:Platelet serotonin of depression was significantly lower than controls.Plasma basal cortisol level and cortisol level after taking dexamethasone were significantly lower in depressive group than in control group.The sensitivity of the dexamethasone suppression test (DST,nonsuppression of cortisol )in depressive group was significantly higher than in control group. Conclusion:There are neurotransmitter and neuroendocrine disturbances in depression.Lower serotonin in depression could explain some of the neuroendocrine disturbances. |
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| Keywords: | Depression Serotonin Prolactin Dexamethasone suppression test(DST) |
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