餐后血糖调节与糖尿病心血管疾病并发症

如何确定餐后高血糖水平及其与糖化血红蛋白(Hb)A1c的相关性,近年来研究结果不一致。虽然高血糖在糖尿病并发症发生、发展中的直接作用目前仍有争议,但众多流行病学研究已证实,与HbA1c相比,餐后血糖是一个更好的预测心血管疾病危险性的因素。其致病机制与氧化应激对血管内皮的毒性作用及其对总体血糖的贡献有关。目前的观点普遍认为,控制餐后血糖是预防与糖尿病相关的心血管疾病并发症的一项重要的策略。

Postprandial glucose regulation and cardiovascular diseases in diabetes

Recently researches about how to determine the association between postprandial hyperglycemia and glycosylated hemoglobin (Hb)A1c remain disagreement. Although the role of hyperglycemia in the occurrence and development of diabetic complications remain controversial now, most epidemiological studies have proved that postprandial hyperglycemia is a better predictor of cardiovascular diseases risk than HbA1c. Postprandial glucose not only may have a toxic effect on the vascular endothelium mediated by oxidative stress, but also may exert its effects through its contribution to total glycemic exposure.The present view is that controlling postprandial glucose is an important strategy in the prevention of cardiovascular complications associated with diabetes.