| 联用阿司匹林氯吡格雷对不稳定型心绞痛病人血小板功能的影响 |
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| 引用本文： | 郭建强,张世新.联用阿司匹林氯吡格雷对不稳定型心绞痛病人血小板功能的影响[J].内蒙古医学院学报,2008,30(3). |
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| 作者姓名： | 郭建强 张世新 |
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| 作者单位： | 内蒙古医学院附属医院,CT室,内蒙古,呼和浩特,010050 |
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| 摘 要： | 目的:以血小板功能变化为指标,评价联用阿司匹林氯吡格雷在不稳定型心绞痛(UAP)病人中的应用价值.方法:选择52例我院住院UAP病人,随机分为联用阿司匹林氯吡格雷组(25例),阿司匹林100mg/d加氯吡格雷75mg/d;单用阿司匹林组(27例),阿司匹林100mg/d.分别于入院时、入院治疗7d后抽取肘静脉血,测定血浆GMP-140浓度及血小板聚集率,观察其治疗前后及在不同治疗组的变化.另选年龄性别都与UAP病人相当的健康者20例作为正常对照组.结果:UAP病人血浆GMP-140及血小板聚集率较正常组明显升高(P＜0.01),且两组间无显著差异;经治疗7d后血浆GMP-140及血小板聚集率明显下降(P＜0.01),联合用药组血浆GMP-140与血小板聚集率明显低于阿司匹林组(P＜0.01);联合用药组治疗后血浆GMP-140浓度仍显著高于正常对照组(P＜0.01),血小板聚集率也显著高于正常对照组(P＜0.05).结论:UAP病人存在血小板活化高聚集状态,目前对于UAP病人的标准治疗可显著抑制血小板活化聚集功能,联用阿司匹林和氯吡格雷在抗血小板活化聚集功能上有显著的疗效,明显优于单用阿司匹林.经双联治疗7d,UAP病人血小板活化聚集功能虽明显减弱,但仍未恢复正常.
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| 关 键 词： | 不稳定型心绞痛 氯吡格雷 血小板 |
EFFECTS OF ASPIRIN ADDING CLOPIDOGREL ON PLATELET FUNCTION IN PATIENTS WITH UNSTABLE ANGINA PECTORIS |
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| GUO Jian-qiang,ZHANG Shi-xin.EFFECTS OF ASPIRIN ADDING CLOPIDOGREL ON PLATELET FUNCTION IN PATIENTS WITH UNSTABLE ANGINA PECTORIS[J].Acta Academiae Medicinae Neimongol,2008,30(3). |
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| Authors: | GUO Jian-qiang ZHANG Shi-xin |
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| Institution: | Department of Cardiology;Affliated Hospital;Inner Mongolia Medical College;Hohhot 010050 China |
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| Abstract: | Objective:To observe the effects of aspirin adding clopidogrel on platelet function in patients with unstable angina pectoris(UAP) and to discuss its clinical value.Methods:52 UAP patients were randomly divided into two groups:aspirin adding clopidogrel group(n=25),aspirin 100mg/d,adding clopidogrel 75mg/d.Aspirin group(n=27),aspirin 100mg/d.In addition,20 healthy subjects were chosen as healthy control group.Blood samples were obtained for the detection of plasma GMP-140 and platelet aggregation rate induc... |
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| Keywords: | unstable angina pectoris clopidogrel platelet |
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