| 30例癫痫患者丙戊酸钠血药浓度监测结果分析 |
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| 引用本文： | 杜延琪,林敬明.30例癫痫患者丙戊酸钠血药浓度监测结果分析[J].中国医院用药评价与分析,2010(5):450-451. |
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| 作者姓名： | 杜延琪 林敬明 |
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| 作者单位： | 南方医科大学;南方医科大学附属珠江医院药剂科; |
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| 摘 要： | 目的：分析癫痫患者丙戊酸钠的血药浓度,指导临床合理用药。方法：采用荧光偏振免疫法测定30例癫痫患者丙戊酸钠血药浓度,并进行分析。结果：在对我院30例癫痫患者丙戊酸钠的血药浓度测定结果中,有6例血药浓度小于50μg·mL-1（占20.00%）,有效率为16.67%;23例血药浓度在50～100μg·mL-1（占76.67%）,有效率为73.91%;1例血药浓度大于100μg·mL-1（占3.33%）,有效率为100.00%。结论：癫痫患者丙戊酸钠血药浓度个体差异大,应及时监测血药浓度,实现个体化用药。
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| 关 键 词： | 丙戊酸钠 癫痫 血药浓度 监测 |
Monitoring Results of Serum Concentration of Sodium Valproate: Analysis of 30 Epileptic Patients |
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| DU Yan-qi,LIN Jing-ming#.Monitoring Results of Serum Concentration of Sodium Valproate: Analysis of 30 Epileptic Patients[J].Evaluation and Analysis of Drug-Use in Hospital of China,2010(5):450-451. |
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| Authors: | DU Yan-qi LIN Jing-ming# |
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| Institution: | DU Yan-qi1,2,LIN Jing-ming2# ( 1. Graduate Student of Southern Medical University,Guangzhou 510515,China,2. Dept. of Pharmacy,Southern Medical University Affiliated Zhujiang Hospital,Guangzhou 510282,China) |
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| Abstract: | OBJECTIVE： To analyze serum concentriaton of sodium valproate in epileptic patients so as to guide clinical rational drug use. METHODS： Serum concentrations of sodium valproate in 30 epileptic cases were determined by fluorescence polarization immunoassay and the results were analyzed. RESULTS： Of the total 30 cases monitored, serum concentrations of sodium valproate in 6 cases （20. 00% ） were less than 50 μg·mL-1 with an effective rate of 16. 67% ,in 23 （76. 67% ） were within 50 ～ 100 μg·mL-1with an effective rate of 73. 91% and in 1 （3. 33% ） was greater than 100 μg·mL-1with an effective rate of 100. 00% . CONCLUSION： There are great individual differences with regard to serum concentration of sodium valproate in in epileptic patients. Timely monitoring of serum concentration of sodium valproatein and individualized therapy are preferable. |
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| Keywords: | Sodium valproate Epilepsy Serum drug concentration Monitoring |
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