| 重组人红细胞生成素注射液中细菌内毒素凝胶检查法的研究 |
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| 引用本文： | 张浩. 重组人红细胞生成素注射液中细菌内毒素凝胶检查法的研究[J]. 中国现代应用药学, 2006, 0(Z1) |
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| 作者姓名： | 张浩 |
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| 作者单位： | 蚌埠医学院第一附属医院药剂科 安徽蚌埠233004 |
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| 摘 要： | 目的本文介绍了一种重组人红细胞生成素注射液的细菌内毒素检查法。方法应用鲎法检查重组人红细胞生成素注射液中的细菌内毒素,考察重组人红细胞生成素注射液对细菌内毒素检查法的干扰。结果重组人红细胞生成素注射液稀释150倍对细菌内毒素检查法无干扰。结论使用凝胶法检查重组人红细胞生成素注射液中的细菌内毒素是可行的,可用细菌内毒素凝胶法代替家兔热原检查法。
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| 关 键 词： | 重组人红细胞生成素注射液 细菌内毒素 凝胶法 干扰试验 |
Apply jel method for studying endotoxin in recombinant human erythropoietin injection |
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| ZHANG Hao. Apply jel method for studying endotoxin in recombinant human erythropoietin injection[J]. The Chinese Journal of Modern Applied Pharmacy, 2006, 0(Z1) |
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| Authors: | ZHANG Hao |
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| Abstract: | OBJECTIVE This article introduces a method to study the bacterial endotoxin test for detecting pyrogen in recombinant human erythropoietin injection.METHODS Limulus reagent was used to detect pyrogen in recombinant human erythropoietin injection,to observe interference of recombinant human erythropoietin injection to bacterial endotoxin test. RESULTS Recombinant human erythropoietin injection in 150-fold dilution had no inerference to the bacterial endotoxin test.CONCLUSION The jel method of bacterial endotoxin test can be used to pyrogen test the endotoxin in recombinant human erythropoietin injection instead of rabbit. |
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| Keywords: | recombinant human erythropoietin injection bacterial endotoxin jel method interfere test |
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