| 抗体导向的酶催化前体药物疗法 |
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| 引用本文： | 张信平. 抗体导向的酶催化前体药物疗法[J]. 中国现代应用药学, 2009, 26(4): 280-284 |
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| 作者姓名： | 张信平 |
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| 作者单位： | 襄樊市第一人民医院药剂科,湖北 襄樊 441000 |
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| 摘 要： | 目的 综述抗体导向的酶催化前体药物疗法（Antibody directed enzyme prodrug therapy，ADEPT）的研究进展，评价这种技术应用的潜力。方法检索近几年国内外研究ADEPT的相关文献，并进行分析、归纳。结果“抗体导向的酶催化前体药物疗法”是一种肿瘤靶向治疗两步策略。该策略以巧妙的设计克服了以往单抗作为药物载体的许多缺陷，通过分子与分子靶标，酶与底物（前药）的双重选择性，提高药物对肿瘤细胞的靶向性，降低毒性，克服耐药性。结论抗体导向的酶催化前体药物疗法是一种极有发展前途的肿瘤靶向疗法。
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| 关 键 词： | 抗体导向的酶催化前体药物疗法 肿瘤靶向 |
| 收稿时间： | 1900-01-01 |
Antibody Directed Enzyme Prodrug Therapy |
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| ZHANG Xinping. Antibody Directed Enzyme Prodrug Therapy[J]. The Chinese Journal of Modern Applied Pharmacy, 2009, 26(4): 280-284 |
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| Authors: | ZHANG Xinping |
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| Affiliation: | ZHANG Xinping ( Department of Pharmaceutical, Xiangfan First People＇s Hospital, Xiangfan 441000, China) |
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| Abstract: | Isoliquiritigenin (ILG) is a flavonoid compound from licorice root.It depends to the chalchon family. ILG can be obtained by the sources of natural extraction and chemical synthesis. This molecule has relatively strong and widespread pharmacological actio |
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| Keywords: | Isoliquiritigenin (ILG) preparation techniques chemical synthesis pharmacological actions |
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