| 绞股蓝总皂甙对大鼠心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 李冬辉,李广元.绞股蓝总皂甙对大鼠心肌缺血再灌注损伤的保护作用[J].基础医学与临床,1990,10(1):29-32. |
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| 作者姓名： | 李冬辉 李广元 |
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| 作者单位： | 西安医科大学药理教研室
(李冬辉，邱培伦)，西安医科大学中西医结合研究所
(李广元)，陕西师范大学(穆启运) |
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| 摘 要： | 结扎大鼠冠状动脉40分钟,解除结扎恢复血流再灌注20分钟,复制大鼠心肌缺血/再灌注损伤模型,观察绞股蓝总皂甙(GP)对心肌缺血/再灌注损伤的影响。结果,GP明显提高心肌组织GSH-Px活性,降低心肌MDA含量,使降低的线粒体膜流动性恢复,减轻再灌注导致心肌超微结构损伤。提示,GP对大鼠心肌缺血/再灌注损伤有保护作用,作用机理与抗氧化作用有关。
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| 关 键 词： | 心肌缺血 再灌注损伤 GP |
Effect of Gypenosides on Myocardial Ischemia/Reperfusion Injury in Rats |
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| Li Donghui Qiu Peilun Li Guangyuan Mu Qiyun.Effect of Gypenosides on Myocardial Ischemia/Reperfusion Injury in Rats[J].Basic Medical Sciences and Clinics,1990,10(1):29-32. |
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| Authors: | Li Donghui Qiu Peilun Li Guangyuan Mu Qiyun |
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| Abstract: | The myocardial ischemia/reperfusion injury model was produced by occlusion the left coronary artery and release the occlusion in rats. 20mg/kg Gypenosides, iv 5 min before releasing the occlusion coronary artery, significantly improved myocardial GSH-Px activity, reduced MDA content and mantained the fluidity of mitochondria membrane in normal level, also protected myocardial ultrastructure, keeped them from the oxygen free radical damage. These results indicate that Gypenosides have protective effect on myocardial ischemia/reperfusion injury probably by inhibiting the oxygen free radicals and subseqence lipid peroxidation. |
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| Keywords: | ischemia/reperfusion iniury oxygen free radical lipid perxoidation Gypenosides |
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