| ~(125)I-海藻酸钠-牛血清白蛋白毫微粒在小鼠体内分布的研究 |
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| 引用本文： | 杨唐玉,易以木,潘卫民.~(125)I-海藻酸钠-牛血清白蛋白毫微粒在小鼠体内分布的研究[J].华中科技大学学报(医学版),1998(5). |
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| 作者姓名： | 杨唐玉 易以木 潘卫民 |
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| 作者单位： | 同济医科大学药学院药物研究室 武汉430030(杨唐玉)，同济医科大学药学院药剂学教研室 武汉430030(易以木)，同济医科大学实验医学研究中心核医学实验室 武汉430030(潘卫民) |
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| 基金项目： | 国家自然科学基金资助项目(No.39270809) |
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| 摘 要： | 用乳液固化方法制备了~(125)I-海藻酸钠-牛血清白蛋白毫微粒,透射电子显微镜测得粒径为(125±73)nm,小鼠口服毫微粒(148×10~8Bq/只)后,主要分布在肝、脾、肺中,心、脑组织中有少量分布,甲状腺和肌肉中无放射计数,微观放射自显影实验表明,毫微粒分布在肝脏的Kupffers细胞和肝实质细胞中,以及在肺和脾脏的吞噬细胞中。实验数据用3P87程序处理,按血管外给药开放二室模型计算得代谢动力参数,T_(max)为2.18h,C_(max)为2.45×10~7Bq,t_1/2为9.42h,AUC为3.9×10~9Bq。
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| 关 键 词： | ~(125)I标记 海藻酸钠-牛血清白蛋白毫微粒 口服给药 体内分布 |
Studies on Distribution of I25I-Sodium Alginate-bovine Serum Albumin Nanoparticle in vivo |
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| Yang Tangyu ,Yi Yimu ,Pan Weimin ' Drug Research.Studies on Distribution of I25I-Sodium Alginate-bovine Serum Albumin Nanoparticle in vivo[J].Journal of Huazhong University of Science and Technology(Health Sciences),1998(5). |
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| Authors: | Yang Tangyu Yi Yimu Pan Weimin ' Drug Research |
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| Institution: | Yang Tangyu 1,Yi Yimu 2,Pan Weimin 3' Drug Research Department,College of Pharmacy,Tongji Medical University,Wuhan 4300302 Department of Pharmaceutics,College of Pharmacy,Tongji Medical University,Wuhan 4300303 Nuclear Medical Laboratory,Research Center of Experiment Medicine,Tongji Medical University,Wuhan 430030 |
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| Abstract: | 125I labeled sodium alginate-bovine serum albumin nanoparticle was prepared with emulsion solidification method with the size being (125?3) nm. After oral administration of nanoparticle (148X108 Bq) to mice,nanoparticle mainly distributed in liver.spleen and lung,little was found in the heart and brain, and no nanoparticle in the muscle. The microhistologicd radioautographic test showed that nanoparticle exist-ed in Kupffer's cells of liver,and RES of spleen and lung. Metaholic dynamic parameters were calculated,in two-compartment model. |
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| Keywords: | I-labeled sodium alginate-bovine serum albumin nanoparticle distribution in vivo |
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