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| ELISA法测定脑脊液中β-葡萄糖醛酸酶及临床意义 | |
| 引用本文： | 宋芷珩,孙晋民,于笑难,李为,张朝东,张弘. ELISA法测定脑脊液中β-葡萄糖醛酸酶及临床意义[J]. 陕西医学杂志, 2004, 33(1): 70-72 |
| 作者姓名： | 宋芷珩 孙晋民 于笑难 李为 张朝东 张弘 |
| 作者单位： | 1. 中国医科大学第二学院二部神经内科,沈阳,110022 2. 中国医科大学技术服务中心一部、第一临床学院、病理教研室 3. 沈阳军区总医院 4. 辽宁省金秋医院 |
| 基金项目： | 辽宁科技攻关计划基金资助项目 (项目号 :982 2 5 0 0 3 ) |
| 摘 要： | 目的 :探讨脑脊液中 β-葡萄糖醛酸酶 ( β- G)活性测定对脑肿瘤诊断的临床意义。方法 :建立酶联免疫吸附试验 ( ELISA)技术测定脑肿瘤及非肿瘤脑病患者脑脊液中 β- G活性。结果 :恶性脑肿瘤患者脑脊液 β- G活性明显高于良性脑肿瘤、非肿瘤脑病患者及其他对照组 ( P<0 .0 1 ) ;恶性脑肿瘤患者术后脑脊液 β- G活性呈下降趋势。结论 :检测脑脊液中β- G活性 ,对恶性脑肿瘤诊断及病程判定有一定的参考价值 |
| 关 键 词： | 脑肿瘤/酶学 β-葡萄糖醛酸酶/酶学 酶联免疫吸附试验 |
Clinical significance of detection of β-G in CSF of patients with cerebral tumor |
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| Affiliation: | Shenyang110022 |
| Abstract: | Objective:To study the clinical significance of the detection of activity of β-G in CSF (cerebrospinal fluid) of patients with cerebral tumor. Methods:Enzyme-linked immunosorbent assay(ELISA) was set up to measure the activity of β-G in CSF of patients with cerebral tumor or and without cerebral tumor. Results: The activity of β-glucuronidase in patients with cerebral malignancy were obviously higher than that in patients with cerebral benign tumor?without cerebral tumor and control group(P<0.01); the activity of β-glucuronidase in CSF of patients with cerebral malignancy was showed descending tendency after operation. Conclusions: To detect the activity of β-glucuronidase in CSF is of reference to diagnosis of cerebral malignancy and determine of the course of the cerebral malignancy. |
| Keywords: | Cerebral tumor/enzymology β-glucuronidase/enzymology Enzyme-linked immunosorbent assay(ELISA) |
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