A RANDOMIZED COMPARISON OF MIDAZOLAM AND DIAZEPAM FOR SEDATION IN UPPER GASTROINTESTINAL ENDOSCOPY |
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| Authors: | MAGNI, V. C. FROST, R. A. LEUNG, J. W. C. COTTON, P. B. |
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| Affiliation: | Department of Anaesthetics The Middlesex Hospital, London W1N 8AA
Department of Gastroen-terology The Middlesex Hospital, London W1N 8AA |
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| Abstract: | One hundred and eighty-five patients were allocated at randomto receive pethidine with diazepam (in an emulsion), or pethidinewith midazolam i.v. as sedation for upper gastrointestinal endpscopy.Sedation and conditions for examination were comparablèand satisfactory in both groups. Midazolam produced more amnmia(P= <0.001), and scored higher in patients' opinion (P= <0.001);it was associated with a slightly greater frequency of venoussequelae, but the difference in thrombophlebitis was not statisticallysignificant. Recovery of sensory - motor performance, as assessedby Trieger test, was still incomplete 2 h after endoscopy with,both drug regimens. |
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