Immunogenetic Studies of Respiratory Anaphylaxis in Selectively Bred Guinea Pigs |
| |
| Authors: | J. T. CLAUSEN, J. V. SPÄ RCK, O. WERDELIN, S. O. LARSEN, L. LUNDBERG |
| |
| Affiliation: | Immunological Laboratory, University of Copenhagen, Denmark;Biostatistical Department, Statens Seruminstitut, University of Copenhagen, Denmark;Institute of Pathology, University of Copenhagen, Denmark;Institute of Medical Microbiology, University of Copenhagen, Denmark |
| |
| Abstract: | The genetic and immunological basis of respiratory anaphylaxis was studied in two strains of guinea pigs selectively bred for either high or low respiratory anaphylactic response to inhalation of ovalbumin. Individuals of the parental strains, Fl-hybrids and backcross offspring were examined for class II MHC type and asthmatic response to ovalbumin. Analysis of the results revealed an association of asthma phenotype and MHC class II type. Apart from the gene(s) in the MHC several other genes seem to be involved in the control of guinea pig asthma. |
| |
| Keywords: | asthma heredity immune response major histocompatibility complex |
|
|
