| 肺腺癌患者血清CEA和蛋白质谱联合检测的临床意义 |
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| 引用本文： | 林艳,林志强,陈慧菁,叶韵斌,林丽婷,陈强. 肺腺癌患者血清CEA和蛋白质谱联合检测的临床意义[J]. 中华肿瘤防治杂志, 2010, 17(3) |
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| 作者姓名： | 林艳 林志强 陈慧菁 叶韵斌 林丽婷 陈强 |
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| 作者单位： | 1. 福建医科大学教学医院(福建省肿瘤医院)肿瘤免疫学研究室,福建,福州,350014
2. 福建中医学院附属人民医院检验科,福建,福州,350004 |
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| 基金项目： | 福建省自然科学基金计划资助项目(X0750024) |
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| 摘 要： | 目的:探讨在肺腺癌患者中联合应用CEA检测和SELDI蛋白芯片技术诊断的价值。方法:应用免疫化学发光技术检测69例肺腺癌患者及71例健康对照者血清标志CEA;同时应用表面增强激光解吸电离飞行时间质谱技术(SELDI-TOF)和CM10芯片检测该血清,经BiomarkerWizard软件分析,结合临床病理资料分析两种手段的联合诊断价值。结果:免疫化学发光法检测CEA的敏感度为62.319%(43/69),特异度为92.958%(66/71);SELDI-TOF-MS技术检测的敏感度为88.406%(61/69),特异度为68.182%(15/22);两者联合检测的敏感度为82.609%(57/69),特异度为92.958%(66/71)。结论:免疫化学发光法检测CEA和SELDI-TOF-MS技术联合检测蛋白标志比单用免疫化学发光法检测CEA能提高对肺腺癌诊断的敏感度。但与单独使用SELDI-TOF-MS技术相比,两者联合检测的敏感度无明显提高。
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| 关 键 词： | 肺肿瘤 腺癌 血清 癌胚抗原 |
Clinical significance of combined application of patients CEA detection and SELDI-TOF-MS technology in lung adenocarcinoma patients |
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| LIN Yan,LIN Zhi-qiang,CHEN Hui-jing,YE Yun-bin,LIN Li-ting,CHEN Qiang. Clinical significance of combined application of patients CEA detection and SELDI-TOF-MS technology in lung adenocarcinoma patients[J]. Chinese Journal of Cancer Prevention and Treatment, 2010, 17(3) |
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| Authors: | LIN Yan LIN Zhi-qiang CHEN Hui-jing YE Yun-bin LIN Li-ting CHEN Qiang |
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| Affiliation: | LIN+Yan1,LIN+Zhi-qiang2,CHEN+Hui-jing1,YE+Yun-bin1,LIN+Li-ting2,CHEN+Qiang11.Immuno+Oncology+Laboratory,Fujian+Provincial+Tumor+Hospital,Fujian+Medical+University%5c's+Teaching+Hospital,Fuzhou+350014,P.R.China2.Clinical+Laboratory,Affiliated+People%5c's+Hospital+of+Fujian+Traditional+Medicine+College,Fuzhou+350004,P.R.China |
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| Abstract: | OBJECTIVE:To study the diagnostic values of co-detections of traditional serum tumor marker,carcino-embryonic antigen (CEA) and serum proteomic patterns by surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technology in patients with lung adenocarcinoma.METHODS:The serum samples of 69 lung adenocarcinoma patients and 71 healthy controls were detected by immunoluminesceme to analyze the levels of CEA,while SELDI-TOF-MS and CM10-chips were employed to detect the ... |
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| Keywords: | iung neoplasms adenocarcinoma serum carcinoembryonic antigen |
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