2011—2013年锦州市妇婴医院鲍曼不动杆菌耐药性分析

目的研究2011—2013年鲍曼不动杆菌的检出率及耐药率的动态变化,为临床治疗提供依据。方法统计2011年1月—2013年10月辽宁省锦州市妇婴医院送检标本中鲍曼不动杆菌检出率、对抗生素的敏感性,细菌鉴定和药敏试验使用的VITEK2全自动微生物分析仪进行分析。结果 3年来分离出鲍曼不动杆菌共计123株。主要来源于痰标本,占89%。连续3年监测中,鲍曼不动杆菌对不同抗生素均有不同程度的耐药,对青霉素类和一二代头孢全部耐药,对其他抗生素的耐药性也逐年增加,其中耐药性上升最明显的是亚胺培南,敏感率由2011年的91.5%下降到2013年的76.5%。其中敏感性最高的是阿米卡星,2013年阿米卡星敏感率是82.4%。结论鲍曼不动杆菌的耐药性逐年增加,多重耐药菌株逐年增多,甚至出现全部耐药的菌株。鲍曼不动杆菌的耐药性进行连续监测,注意抗生素使用的合理性。

Analysis of drug resistance of acinetobacter baumanii from 2011 to 2013

Objective To investigate the detection rate, and dynamic changes of drug resistance of acinetobacter baumannii from2011 to 2013,in order to provide evidence for clinical therapy. Methods We gathered samples from Women and Children＇s Hospital of jinzhou and analyzed the data of the detection rate and drug resistance of the acinetobacter baumannii. Identification of bacteria and drug sensitive test were analysed by VITEK2 Automatic microbial analyzer. Results For 3 years we have isolated 123 strains of acinetobacter baumannii,The target bacteria were mainly from sputum specimens, accounting for 89%.We also found that there was varying degrees of tolerance for acinetobacter baumanii to different antibiotics after monitoring for three consecutive years.It has become totally tolerated to penicillins and generation I/II cephalosporin and its tolerance to other antibiotics increases year by year The tolerance to imipenem increased most obviously and its sensibility has decreased from 91.5% in 2009 to 76.5%in 2013.And amikacin is the most sensitive with a sensibility of 82.4% in 2013. Conclusion The tolerance of acinetobacter baumanii increased year by year and multidrug resistant bacteria strains also increased as time was coming and even it appeared all drug-resistant strains. But at the same time rational use of antibiotics should be considered carefully.