Vimentin and glial fibrillary acidic protein in human brain tumors |
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Authors: | Wai-Kwan A Yung Mario Luna Adam Borit |
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Affiliation: | (1) Section of Neurology and Department of Pathology, University of Texas System Cancer Center, MD, USA;(2) Anderson Hospital and Tumor Institute and Departments of Neurology and Pathology, University of Texas Medical School at Houston, Houston, Texas, USA;(3) MD Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, 77030 Houston, TX, USA |
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Abstract: | Using the peroxidase-antiperoxidase (PAP) technique, we examined 35 primary brain tumors for expression of vimentin and GFAP. Both low-grade and high-grade astrocytomas contained vimentin-positive and GFAP-positive cells. Ependymomas also stained for both markers. In gliosarcomas, the glioblastomatous portions stained like astrocytomas, while only vimentin stain was seen in the fibrosarcomatous portions. Medulloblastomas and oligodendrogliomas were negative for both vimentin and GFAP, while meningiomas contained scattered areas of vimentin-positive cells. These results suggest that the expression of vimentin and GFAP is mostly confined to glial-derived tumors, and that vimentin can potentially be a useful marker for distinguishing undifferentiated GFAP-negative glial tumors and mesenchymal tumors from primitive neuroectodermal tumors. |
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Keywords: | Glial fibrillary acidic protein vimentin intermediate filament brain tumors |
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