| 盐酸哌甲酯-卵磷脂微乳的制备及其透皮吸收作用 |
| |
| 引用本文： | 俞媛,高中,陈琰,钟延强,程明和. 盐酸哌甲酯-卵磷脂微乳的制备及其透皮吸收作用[J]. 中国药学杂志, 2005, 40(11): 843-845 |
| |
| 作者姓名： | 俞媛 高中 陈琰 钟延强 程明和 |
| |
| 作者单位： | 1. 第二军医大学药学院药剂学教研室,上海,200433
2. 第二军医大学药学院药理教研室,上海,200433 |
| |
| 基金项目： | 上海市-SK研究与发展基金 |
| |
| 摘 要： | 目的探讨微乳作为载体促进水溶性药物盐酸哌甲酯的透皮吸收。方法以十四酸异丙酯-水-卵磷脂-乙醇作为微乳的组成部分,对微乳伪三元相图进行了研究,制备盐酸哌甲酯-卵磷脂油包水微乳,采用Franz扩散池,裸鼠离体皮肤作为透皮模型,HPLC测定药物透皮浓度,计算微乳的经皮渗透稳态流量,并与盐酸哌甲酯-卵磷脂混悬液和哌甲酯溶液作出对比。结果盐酸哌甲酯-卵磷脂油包水微乳的透皮稳态流量大于2个对照组(P<0.01)。结论微乳对盐酸哌甲酯的经皮渗透具有促进作用。
|
| 关 键 词： | 透皮 微乳 盐酸哌甲酯 |
| 文章编号： | 1001-2494(2005)11-0843-03 |
| 收稿时间： | 2004-10-25; |
Preparation of methylphenidate hydrochloride microemulsion and its transdermal delivery effect |
| |
| YU Yuan,GAO Shen,CHEN Yan,ZHONG Yan-qiang,CHENG Ming-He. Preparation of methylphenidate hydrochloride microemulsion and its transdermal delivery effect[J]. Chinese Pharmaceutical Journal, 2005, 40(11): 843-845 |
| |
| Authors: | YU Yuan GAO Shen CHEN Yan ZHONG Yan-qiang CHENG Ming-He |
| |
| Affiliation: | 1.Department of Pharmaceutics， College of Pharmacy， Second Military Medical University， Shanghai 200433，China； 2.Department of Pharmacology， College of Pharmacy， Second Military Medical University,Shanghai 200433, China |
| |
| Abstract: | OBJECTIVE To prepare W/O microemulsion formulation containing methylphenidate hydrochloride (MPH) and to investigate its transdermal delivery effect in vitro. METHODS The microemulsion was prepared with the system contained of isopropyl-water-lecithin-ethanol according to the phase diagram. The steady state flux and lag time of MPH were determined in vitro using Franz diffusion cell with nude rats skin. The concentration of MPH was measured by HPLC. The transdermal characteristics of MPH microemulsion across the nude rats skin were compared with control preparations. RESULTS The steady state flux of MPH microemulsion was significantly higher than the control preparations. CONCLUSION Microemulsion enhanced the penetration of MPH across nude rats skin( P < 0.01). |
| |
| Keywords: | transdermal delivery microemulsion methylphenidate hydrochloride |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药学杂志》下载免费的PDF全文 |
|
