| Clinical significance of VEGF, ER and AR expression in seminoma |
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| 作者单位： | J.Z. Wang，P.D. Mao，D.L. Zeng，J.J.Wang，X.Y. Xie，Z.J. Zhu，J.Y. Zhou Affiliated Hospital of North Sichuan Medical College，Nanchong，Sichuan 637000，China |
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| 摘 要： | To evaluate the expression of vascular endothelial growth factor (VEGF), estrogen receptor (ER) and androgen receptor (AR) in the genesis and development of seminoma. Methods: The expression of VEGF, ER and AR was assayed by means of immuno-histochemical technique in 16 cases of seminoma and 10 cases of prostatic cancer (Pca). Results: The VEGF expression positive rate was significantly higher (P<0.05) in seminoma than in Pca, being 14/16(87.5 %) and (4/10, 40%), respectively. The AR expression positive rate was lower (P>0.05) in seminoma (9/16, 56.2%) than in Pca (9/10, 90%). The ER expression was negative in all the seminoma and Pca patients. Conclusion: In seminoma, the expression of VEGF is significantly increased, which may play a role in the genesis and development of the neoplasm. (Chin J Androl 2002; 16: 349)
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Clinical significance of VEGF, ER and AR expression in seminoma |
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| Authors: | JZ Wang PD Mao DL Zeng JJWang XY Xie ZJ Zhu JY Zhou Affiliated Hospital of North Sichuan Medical College Nanchong Sichuan China |
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| Institution: | J.Z. Wang,P.D. Mao,D.L. Zeng,J.J.Wang,X.Y. Xie,Z.J. Zhu,J.Y. Zhou Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China |
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| Abstract: | To evaluate the expression of vascular endothelial growth factor (VEGF), estrogen receptor (ER) and androgen receptor (AR) in the genesis and development of seminoma. Methods: The expression of VEGF, ER and AR was assayed by means of immuno-histochemical technique in 16 cases of seminoma and 10 cases of prostatic cancer (Pca). Results: The VEGF expression positive rate was significantly higher (P<0.05) in seminoma than in Pca, being 14/16(87.5 %) and (4/10, 40%), respectively. The AR expression positive rate was lower (P>0.05) in seminoma (9/16, 56.2%) than in Pca (9/10, 90%). The ER expression was negative in all the seminoma and Pca patients. Conclusion: In seminoma, the expression of VEGF is significantly increased, which may play a role in the genesis and development of the neoplasm. (Chin J Androl 2002; 16: 349) |
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| Keywords: | seminoma sex hormone receptor vascular endothelial growth factor |
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