维生素D受体TaqⅠ基因多态性与糖尿病视网膜病变的关系

目的 探讨维生素D受体(VDR)TaqⅠ基因多态性与糖尿病视网膜病变(DR)的关系。 方法 应用片段长度差异等位基因特异性多聚酶链反应(FLDAS-PCR)技术，检测158例DR患者和198名正常对照者的VDRTaqⅠ基因多态性。 结果 VDRTaqⅠ基因型在DR患者中的分布为TT型106例，占67.1%,Tt型33例，占20.9%,tt型19例，占12.0%;在正常对照者中的分布为TT型165例，占83.3%，Tt型23例，占11.6%,tt型10例占5.1%。DR患者与正常对照者TT、Tt、tt基因型分布差异有统计学意义(P<0.05)。结论 DR与维生素D受体TaqⅠ基因多态性有一定的关系。 (中华眼底病杂志， 2006， 22： 94-96)

The relationship between vitamin D receptor gene Taq Ⅰ polymorphism and diabetic retinopathy

Objective To investigate the polymorphism of the vitamin D receptor gene (VDR)TaqⅠin relation to diabetic retinopathy. Method Fragment length discrepant allele specific PCR(FLDAS-PCR) were used to determine VDR genetypes in 158 patients with diabetic retinopathy and in 198 normal subjects. Results The frequency distribution of VDR genotypes in diabetic retinopathy patients was 106 (67.1%) in TT, 33(20.9%) in Tt, 19(12.0%) in tt; and in normal persons was 165 (83.3%) in TT, 23(11.6%) in Tt, 10 (5.1%) in tt. There was a significant difference between diabetic retinopathy patients and normal persons in distribution of VDR gene TaqⅠgenotypes(P<0.05). Conclusions There is some distribution alterations of VDR gene polymorphism in diabetic retinopathy patients. (Chin J Ocul Fundus Dis, 2006, 22: 94-96)