| 恩替卡韦治疗慢性乙型肝炎病毒感染患者50例的短期疗效观察 |
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| 引用本文： | 纪冬,陈国凤,李永纲,邵清,韩萍.恩替卡韦治疗慢性乙型肝炎病毒感染患者50例的短期疗效观察[J].中华实验和临床感染病杂志（电子版）,2008,2(2):59-63. |
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| 作者姓名： | 纪冬 陈国凤 李永纲 邵清 韩萍 |
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| 作者单位： | 解放军第302医院感染七科,北京市,100039 |
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| 基金项目： | 国家自然科学基金(30700713) |
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| 摘 要： | 目的 分析恩替卡韦对慢性HBV感染患者的早期疗效,提高治疗水平.方法 根据化验结果选取慢性HBV感染患者,给予恩替卡韦抗病毒治疗,将其分为HBeAg阳性组(30例)及HBeAg阴性组(20例)进行观察,在用药2周后检测血清HBV DNA水平及肝功能的变化.结果恩替卡韦在开始治疗2周后即有显著的抗病毒效果.用聚合酶链反应(PCR)定量法检测患者HBV DNA的平均下降幅度,HBeAg阳性、阴性组分别为3.005 log10和3.410 log10,与用药前比较P值均＜0.001.HBV DNA＜500拷贝/ml者分别为1例及8例.没有发生药物相关的不良反应.结论恩替卡韦进行慢性HBV感染者抗病毒治疗,疗效确切,且起效快,安全性好.
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| 关 键 词： | 恩替卡韦 抗病毒治疗 慢性乙型肝炎病毒感染 |
Clinical observation on 50 cases of chronic hepatitis B virus infection patients treated with entecavir |
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| JI Dong,CHEN Guo-feng,LI Yong-gang,SHAO Qing,HAN Ping.Clinical observation on 50 cases of chronic hepatitis B virus infection patients treated with entecavir[J].Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Version),2008,2(2):59-63. |
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| Authors: | JI Dong CHEN Guo-feng LI Yong-gang SHAO Qing HAN Ping |
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| Institution: | JI Dong CHEN Guo-feng LI Yong-gang SHAO Qing HAN Ping |
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| Abstract: | Objective To evaluate the early efficacy of entecavir(ETV) for patients of chronic hepatitis B virus(HBV) infection and improve the treatment level.Methods The patients were divided into HBeAg positive group(30 cases) and HBeAg negative group(20 cases) according to the results of HBV serology,and were administered with ETV and liver protectant drugs.After 2 weeks,HBV DNA level(measured by quantitative PCR) and liver function were tested.Results Significant reduction of HBV DNA could be detected by PCR assay... |
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| Keywords: | Entecavir Antiviral therapy Chronic HBV infection |
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