慢性缺氧性肺动脉高压大鼠内皮素肾素血管紧张素变化

为研究组织局部肾素血管紧张素系统（ＲＡＳ）和内皮素对缺氧性肺动脉高压（ＰＡＨ）的影响。采用常压缺氧ＰＡＨ动物模型，观察血液、右心室、肺组织肾素活性（ＲＡ）、血管紧张素Ⅱ（ＡｎｇⅡ）、血管紧张素转换酶（ＡＣＥ）及内皮素（ＥＴ）含量变化和西拉普利（Ｃｉｌａｚａｐｒｉｌ）的治疗作用。结果发现缺氧时血ＲＡ与对照组无显著差别，ＡｎｇⅡ、ＥＴ升高，ＡＣＥ下降。右心室肌的ＲＡ、ＡｎｇⅡ、ＥＴ升高。肺组织ＲＡ、ＡｎｇⅡ升高，而ＥＴ、ＡＣＥ与对照组无显著差别，Ｃｉｌａｚａｐｒｉｌ使血、肺组织ＡＣＥ、心肌ＡｎｇⅡ降低。结论为１．心肺组织ＲＡＳ与ＰＡＨ的发生有关；２．Ｃｉｌａｚａｐｒｉｌ治疗ＰＡＨ有效。

Changes of Endothelin-1 and Renin-Angiotensin-System in Rats with Hypoxic Pulmonary Hypertension

Cbjective: To study the effects of the tissue renin-angiotensin system (RAS) and endothelin (ET) on rats with hypoxic pulmonary hypertension (PAH).Method:Normobaric hypoxic PAH animal model was adopted.We studied the changes of renin and angiotensin converting enzyme (ACE) activities and angiotensin (Ang )and ET content in the blood,right ventricle and lung tissue and observed the theraputic effects of cilazapril.Results:During hypoxia,plasma ang and ET content increased while ACE activity decreased significantly.But comparing to control group,plasmo renin activity(PRA) showed no significant difference.Right ventricular renin activity (RA).Ang and ET contents increased significantly in hypoxic rats.In the lung tissue of hypoxic rats, Ang contents increased whereas there were no significant difference in ET content and ACE activity between hypoxia and control groups.The ACE activity in plasma and lung tissue decreased significantly after the treatment with cilazapril.Conclusions:The tissue RAS in heart and lung play some role in the pathogenesis of PAH,Cilazapril was effective in treating PAH.