制霉菌素口腔双层贴膜在口腔内释药动态研究

目的：测定自制的制霉菌素口腔双层贴膜在口腔内释药过程。方法：采用剩余量法测定制霉菌素口腔双层贴膜在口腔内释药情况,测定制霉菌素口腔双层贴膜体外释放度,并比较体内外释放的相关性。结果：体外释放方程：ln（100-Q）=-0.089t＋4.998,r=0.997 0,口腔内释药方程为ln（100-P）=-0.022t＋5.014,r=0.993 5。以体内平均释放百分率（Y,%）对体外平均释放百分率（X,%）回归,得方程Y=0.990X＋0.372,r=0.998 0。结论：体内外释放度具有良好的相关性,可以用体外释放度来预测药物的释放。

Dynamic Research on the Drug Release in Oral Cavity of Nystatin Buccal Double layer Films

Objective: To determine the oral drug release property in oral cavity of self-made nystatin buccal double-layer films.Method: The oral drug release in oral cavity of nystatin buccal double-layer films was detected by the residual quantity method,and the release in vitro was determined.The correlation of the release rate in vivo and in vitro was compared.Result: The equation of drug release in vitro was ln(100-Q)=-0.089t+4.998(r=0.997 0),and that of drug release in vivo was ln(100-P)=0.022t+5.014(r=0.993 5).The regression equation of average release rate in vivo(Y%) and the average release rate in vitro(X%) was Y=0.990X+0.372(r=0.998 0).Conclusion: The release rate in vivo and in vitro have a good correlation and the release rate in vitro can be used to predict the drug release in vivo.