低级别、高级别卵巢浆液性癌临床病理分析及CA125、p53和Ki-67表达的意义

[目的]探讨低、高级别卵巢浆液性癌中CA125、p53和Ki-67的表达及其与预后的相关性.[方法]依照两级分级系统对卵巢浆液性癌进行分级,分别选取低级别浆液性癌31例和高级别癌31例,观察其临床病理特点,并采用免疫组织化学SP法检测癌组织中CA125、p53和Ki-67的表达情况.[结果]低级别组p53阳性率显著低于高级别组(32.26％ vs 74.19％,P＜0.001),Ki-67阳性指数显著低于高级别组(29.03％vs80.65％,P＜0.001);低级别组5年总生存率、无病生存率均优于高级别组(P＜0.05).[结论]两级分级系统对卵巢浆液性癌的预后判断具有提示意义,CA125、p53和Ki-67在卵巢低、高级别浆液性癌中的表达差异有统计学意义.

Clinicopathologic Analysis of Low-and High-grade Ovarian Serous Carcinomas and Significance of CA125,p53 and Ki-67 Expression

[Purpose] To investigate the expression of CA125,p53,Ki-67 protein and their prognostic values for low-and high-grade ovarian serous carcinomas.[Methods] A total of 31 cases of low-grade and 31 cases of high-grade ovarian serous carcinomas were selected based on the two-tier grading system.Immunohistochemistry was used to detect CA125,p53 and Ki-67 protein expression in all cases.Correlation of the two-tier system with immunohistochemical results and prognostic parameters were performed.[Results] Significant differences in protein expressions were found between the low-and high-grade serous carcinomas.The high-grade serous carcinomas had a significantly higher expression level of p53（32.26% vs 74.19%,P0.001） and Ki-67（29.03% vs 80.65%,P0.001）.The overall survival,disease-free survival and 5-year survival rates were significantly higher in the low-grade serous carcinoma cases than those in the high-grade cases（P0.05）.[Conclusions] The two-tier system for grading ovarian serous carcinomas shows a good predicting value for prognosis.There are significantly differences in expressions of CA125,p53 and Ki-67 between low-and high-grade ovarian serous carcinomas.